Publications (105)
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In vivo Biocompatibility and Toxicity Assessment of a Gentamicin-Loaded Monoolein Gel Intended to Treat Chronic Osteomyelitis
Moustapha Ouédraogo, Melanie Sanou, Norbert Ramde, Olga Goumbri, Touridomon Issa Some, Rasmané Semdé University of Ouagadougou View profile Rasmata Ouédraogo Universite joseph ki zerbo Ouagadougou View profile Innocent P. Guissou, Viviane Henschel, Brigitte Evrard, Karim Amighi and Jacques Dubois
[en] Biocompatibility and preliminary toxicity of a novel gentamicin-loaded monoolein gel (implant) intended for the local treatment of chronic osteomyelitis were investigated in mice. The mice, randomly allotted in 3 groups of 10, received respectively a single dose (0.05 mL) of normal saline, monoolein and the gel by subplantar injection. Cl(...)
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In vitro biocompatibility and genotoxicity assessment of a gentamicin-loaded monoolein gel intended to treat of chronic osteomyelitis
Moustapha Ouédraogo, Nacoulma Eric, Rasmané Semdé, Touridomon Issa Some, Innocent Pierre Guissou, Viviane Henschel, Brigitte Evrard, Karim Amighi and Jacques Dubois
[en] The aim of the study was to assess in vitro the biocompatibility and the genotoxicity of a gentamicin-loaded monoolein gel intended to treat of chronic osteomyelitis. Indeed, we are developing biodegradable implants based on monoolein and gentamicin. The results of formulations, physico-chemical characterization of the formulated implants(...)
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Automédication dans le traitement de l’accès palustre: étude auprès de clients d’officines pharmaceutiques privées de la ville de Ouagadougou, Burkina Faso
L T Ouédraogo, Touridomon Issa Somé, M DiarraI et P Guissou
Afin de contribuer à un débat national sur le changement de protocole de traitement du paludisme simple au Burkina Faso, nous avons réalisé une étude transversale descriptive auprès de 397 clients de 45 officines privées de la ville de Ouagadougou.Nous avons noté que la chloroquine (39, 3%), la sulfadoxine-pyriméthamine (24, 4%) et l'artémisin(...)
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Self-medication in the treatment of acute malaria: study based on users of private health drug stores in Ouagadougou, Burkina Faso
L T Ouédraogo, Touridomon Issa Somé, M DiarraI et P Guissou
In order to contribute to the national debate on the change of protocol of the simple forms of malaria treatment in Burkina Faso, we conducted a transversal descriptive study among 397 private pharmacies users in Ouagadougou. The aims of the study were:-making an inventory of the antimalarials and signs which led to self-medication;-identifyin(...)
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Preliminary Clinical Assessment of a Gentamicin-Loaded Monoolein Gel Intended to Treat Chronic Osteomyelitis
Moustapha Ouédraogo, Christophe S. Da, Innocent S. Nacoulma, Hamado Kafando, Rasmané Semdé, Touridomon Issa Some, Rasmata Ouédraogo, Innocent P. Guissou, Jacques Dubois and Karim Amighi,
The aim of this study was to perform a preliminary clinical assessment of efficacy and safety of a biodegradable gentamicin-loaded monoolein gel. An open single dose, one treatment study including 19 patients with chronic osteomyelitis caused by a microorganism sensitive to gentamicin was conducted. After surgical curettage of the infected bon(...)
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Monoolein–water liquid crystalline gels of gentamicin as bioresorbable implants for the local treatment of chronic osteomyelitis: in vitro characterization
Moustapha Ouédraogo , Rasmané Semdé , Issa Touridomon Somé , Rasmata Traoré/Ouédraogo, , Innocent Pierre Guissou , Viviane Henschel and Jacques Dubois
To maximize the efficacy of chronic osteomyelitis antibiotherapy while reducing antibiotic systemic toxicity, as well as time and costs of hospitalizations, it has been thought that monoolein–water gels incorporating gentamicin sulfate could be used as local, bioresorbable, and sustained-release implants. For this purpose, four formulations we(...)
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Carotenoids Content of Some Locally Consumed Fruits and Yams in Cameroon
Gouado Inocent, Aba Richard Ejoh, Touridomon Issa Some, Florian J Schweigert, Tchouanguep M.F
Vitamin A deficiency constitutes a public health problem in Cameroon. Data on provitamin A content of fruits locally consumed are scarce. To solve this nutritional problem, it is important to promote the consumption of yellow/orange fruits or green leafy vegetables which are rich sources of provitamin A. In order to achieve this, the carotenoi(...)
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Influence of malaria on the serum levels of vitamin A, zinc and calcium of children in Douala-Cameroon
Gouado Inocent, Lehman Leopold Gustave, Some Issa T., Mbouyap Yolande, PankouiMfonkeu Joel Bertand, Ejoh Aba Richard and Tchouanguep Mbiapo Felicité
Malaria is an endemic parasitic disease that prevails particularly in warm tropical regions of the world. Micronutrient malnutrition such as vitamin A and iron deficiencies which is a public health problem in Cameroon is usually highly prevalent in malaria endemic areas. Characterizing the relationship between micronutrient status (vitamin A,(...)
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Influence of malaria on the serum levels of vitamin A, zinc and calcium of children in Douala-Cameroon
Gouado Inocent, A. O. Adebiyi, Leopold G Lehman,Touridomon Issa Some, Yolande Mbouyap, Joel Bertand Pankoui Mfonkeu, Aba Richard Ejoh, Felicité Tchouanguep Mbiapo
Malaria is an endemic parasitic disease that prevails particularly in warm tropical
regions of the world. Micronutrient malnutrition such as vitamin A and iron deficiencies which
is a public health problem in Cameroon is usually highly prevalent in malaria endemic
areas. Characterizing the relationship between micronutrient status(...)
Malaria, vitamin A, zinc, calcium
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The positive impact of red palm oil in school meals on vitamin A status: study in Burkina Faso
Zeba Augustin, Yves Martin-Prevel, Touridomon Issa Some and Hélène Delisle
Vitamin A (VA) deficiency is widespread in sub-Saharan Africa and school-age children are a vulnerable group. In Burkina Faso, the production and consumption of red palm oil (RPO) is being promoted as a food supplement for VA. The objective of the study was to assess the impact on serum retinol of adding RPO to school lunch in two test zones o(...)
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Validation d'une méthode de dosage des caroténoïdes par CLHP: application à la détermination de teneur en caroténoïdes dans dix variétés de patates douces (Ipo...
Issa T. Somé , Marie-Noël Zagré , Patrick E. Kafando , Mohamed Ag Bendech , Shawn K. Baker , Hélène Deslile , Pierre I. Guissou
Résumé La carence en vitamine A (CVA) concerne plus de 250 millions d'enfants âgés de moins de cinq ans dans le monde. Cette carence et ses conséquences sanitaires sont surtout ressenties dans les pays en voie de développement. Trois approches complémentaires sont préconisées pour remédier aux conséquences de la carence en vitamine A: la suppl(...)
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Prévalence du déficit en Glucose-6-Phosphate Déshydrogénase (G6PD) et de la Drépanocytose chez les nouveau-nés à Ouagadougou (Burkina Faso)
E. Kafando, M. Sawadogo, E. Youl, E. Kabré, E. Nacoulma
Le déficit en G6PD et la drépanocytose sont deux pathologies héréditaires du globule rouge responsables d'anémie hémolytiques. ces deux affections souvent associées sont fréquentes dans la population africaine où elles se superposent aux zones d'endémie palustre. l'objectif de notre étude était de déterminer la prévalence de ces deux pathologi(...)
déficit en G6PD, drépanocytose
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Stability parameter estimation at ambient temperature from studies at elevated temperatures
Touridomon Issa Some, Philippe Bogaerts, Raymond Hanus, Jacques Dubois and Michel Hanocq
The determination of specific kinetic constants ki in pH–profile studies is often undertaken at ambient temperature. However, when dealing with a drug substance that is stable at ambient temperature, the pH–profile study is conducted at a chosen elevated temperature and the kinetic parameters are given at this particular elevated temperature.(...)
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Improved kinetic parameter estimation in pH-profile data treatment
I T Some, P Bogaerts, R Hanus, M Hanocq, J Dubois
Statistical problems in temperature stability parameter estimation have been the subject of many papers whereas statistics in, pH-profile parameter estimation have focused little attention. However, the conventional two step method used in data treatment in both cases leads to identical statistical problems. The aim of this study is then to in(...)
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Incorporating batch effects in the estimation of drug stability parameters using an Arrhenius model
I T Some, P Bogaerts, R Hanus, M Hanocq, J Dubois
The nonlinear estimation of drug stability parameters (energy of activation E a and shelf-life t Y) by conventional approaches employs equations relating drug content determination C at time t and temperature T. The identification procedures lead to the determination of only one initial drug content C 0 for several different experiments. Howev(...)
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