Publications (105)
ARTICLE
Pharmaceutical approaches for enhancing solubility and oral bioavailability of poorly soluble drugs
Isaïe Nyamba , Charles B Sombié, Moussa Yabré , Hermine Zimé-Diawara , Josias Yaméogo , Salfo Ouedraogo , Anna Lechanteur, Rasmané Semdé , Brigitte Evrard
High solubility in water and physiological fluids is an indispensable requirement for the pharmacological efficacy of an active pharmaceutical ingredient. Indeed, it is well established that pharmaceutical substances exhibiting limited solubility in water are inclined towards diminished and inconsistent absorption following oral administration(...)
Formulation, Solubility, Dissolution rate, Bioavailability
ARTICLE
Association de polymères pour le développement de dispersions solides à base d’acide ellagique par extrusion à chaud
Isaïe NYAMBA, Charles B SOMBIE , Hermine ZIME, Josias B.G. YAMÉOGO , Rasmané SEMDE
Dans cette étude, l’extrusion à chaud a été utilisée comme stratégie d’amélioration des
propriétés physicochimiques de l’acide ellagique. En effet, l'acide ellagique est un
composé polyphénolique de classe IV selon la classification biopharmaceutique. Il
possède des propriétés antipaludiques. Cependant, son potentiel thérapeutique reste
in(...)
Acide ellagique, Eudragit EPO, Soluplus, dissolution, dispersions solides
ARTICLE
Potential of Native Cyclodextrins and L-Lysine for Enhancing Ellagic Acid Aqueous Solubility
Isaïe Nyamba, Charles B Sombie, Anna Lechanteur, Rasmané Semde, Brigitte Evrard
This study aimed to examine the influence of β cyclodextrin (βCD) and γ cyclodextrin (γCD) alone and in combination with L-lysine on ellagic acid (EA) solubility. Indeed, complexation with cyclodextrins can be used to improving the solubility of drugs poorly soluble in water such as EA. EA is a Biopharamceutical Classification System (BCS) IV(...)
Antimalarial, L-lysine, Cyclodextrins, Ellagic acid
ARTICLE
Study of harmful vaginal practices of women in the Municipality of Ouagadougou, Burkina Faso
Daniel Dori, Ramata Porgo, Hyacinthe Zamané, Nicolas Méda, Rasmané Semdé
Introduction: Vaginal practices include washing, altering, cutting, cleaning, enhancing, drying, tightening, lubricating, or loosening of the vagina, labia, clitoris, or hymen. This study aimed to investigate the different vaginal practices of women using non-pharmaceutical products. Methodology: This was a cross-sectional study with descripti(...)
Vaginal Practices, Women, Adverse Events
ARTICLE
Systematic Review of Chemical Compounds with Immunomodulatory Action Isolated from African Medicinal Plants
by Wendwaoga Arsène Nikiema ,Moussa Ouédraogo ,Windbedma Prisca Ouédraogo ,Souleymane Fofana ,Boris Honoré Amadou Ouédraogo,Talwendpanga Edwige Delma, Belem Amadé ,Gambo Moustapha Abdoulaye ,Aimé Serge Sawadogo ,Raogo Ouédraogo and Rasmané Semde ,
A robust, well-functioning immune system is the cornerstone of good health. Various factors may influence the immune system’s effectiveness, potentially leading to immune system failure. This review aims to provide an overview of the structure and action of immunomodulators isolated from African medicinal plants. The research was conducted acc(...)
medicinal plants; phytochemicals; immunomodulators; transduction mechanisms
ARTICLE
Chapter 22 - Supercritical fluid methods for liposome production and sterilization
Noémie Penoy, Kouka Luc Delma, Manon Berger, Brigitte Evrard, Géraldine Piel
Despite the numerous laboratory-scale methods available for producing liposomes, only a few are used for commercial manufacturing, delivering liposomes with the necessary critical quality attributes without the use of organic solvents, in Good Manufacturing Practices conditions, and with a low number of unit operations. Similarly, conventional(...)
Mots clés non renseignés
ARTICLE
Etude des connaissances, attitudes et pratiques sur la consommation de tabac des étudiants en sciences de la santé de l’Université Joseph KI-ZERBO
Abdoul Ouadoudou MANDE, Daniel DORI, Kouka Luc DELMA, Bavouma Charles SOMBIE, Rasmané SEMDÉ
Introduction : L’Organisation mondiale de la santé (OMS) estime que la consommation de tabac tue six millions de personnes chaque année. Ses conséquences sur la santé sont multiples. Cependant, il existe peu de données récentes sur le tabagisme des étudiants en sciences de la santé au Burkina Faso. Notre étude a donc pour but d’étudier ce phén(...)
Tabagisme, effets nocifs, attitudes, étudiants
ARTICLE
Study of the Management and Disposal Practices of Unused or Out-of-Date Medicines by Households in the Municipality of Ouagadougou, Burkina Faso
Dori, D., Guembré, A., Ouoba, K., Méda, N. and Semdé, R.
Introduction: Not all medicines that pass-through consumers’ hands are used, and some often expire in households. These health products can be sources of accidental risks and pollution when they are not properly disposed of. In Burkina Faso, there are as yet no guidelines for the disposal of unused medicines in households. The aim of this stud(...)
Unused Medicines, Expired Medicines, Disposal, Household
ARTICLE
Analysis of the conditions for the creation of pharmaceutical university spin-offs within a public university in Burkina Faso
Dori D, Nassouri SG, Toe Djiguimde SLNTM, Ouedraogo R, Semdé R
This study aimed to analyze the legal framework for the creation of university spinoffs, particularly those in the fields of medicine and pharmacy in Burkina Faso. This was carried out through a literature review, supplemented by interviews with resource persons from the sectors in charge of commerce, industry, finance, scientific research and(...)
Spin-off, economic development, research, innovation
ARTICLE
Dengue epidemic in Burkina Faso: concerns about the informal use of traditional herbal remedies
Kampadilemba Ouoba, Daniel Dori, Rasmané Semdé
In response to this latest outbreak of dengue fever, the Ministry of Health and Public Hygiene has undertaken several vector control measures to stop the transmission of this arbovirosis. It has also urged the public to refrain from self-medicating with any suspected symptoms of dengue fever, particularly to avoid using non-steroidal anti-infl(...)
Dengue epidemic, traditional herbal remedies, public health issues
ARTICLE
Pharmacognostical studies and phytochemical evaluation of four Meliaceae plants widely use in ethnomedicine across West Africa.
Aminata P Nacoulma, Yissé Kassoum Combia, Naamwin-So-Bawfu R Meda, Cheick A Noukami Palm, Alain Bambara, Boubacar Yaro and Elie Kabre
Meliaceae plants are widely used in traditional medicine across West Africa, including well-documented
analgesic and anti-inflammatory effects. This study describes assessments for the standardization of
powders from the leaves and bark of these plant materials. Pharmacognostical studies carried out by
macroscopic and microscopic evaluation(...)
Standardization, pharmacognostical studies, phytochemical evaluation
ARTICLE
Connaissances et perception des agents de Santé sur les visites de promotion des médicaments réalisées par les visiteurs médicaux à Ouagadougou
Daniel Dori, Frédéric Eric Sawadogo, Aboubacar Sangho, Boumbéwendin Gérard Josias Yameogo, Nicolas Meda, & Rasmané S.ané Semdé
Introduction : Les ressources financières allouées à la promotion médicale sont considérables. L’objectif de ce travail était de décrire la perception des agents de santé sur les pratiques des visites de promotion médicale.
Méthodes : Il s’est agi d’une étude transversale descriptive qui a concerné des hôpitaux et des officines pharmaceutique(...)
Visiteurs médicaux, promotion médicale
ARTICLE
Development and optimization of a one step process for the production and sterilization of liposomes using supercritical CO2
Noémie Penoy, Kouka Luc Delma, Nirmayi Homkar, Abdoul Karim Sakira, Sabrina Egrek, Rosalie Sacheli, Pierre-Yves Sacré, Bruno Grignard, Marie-Pierre Hayette, Touridomon Issa Somé, Rasmané Semdé, Brigitte Evrard, Géraldine Piel
Liposomes are very interesting drug delivery systems for pharmaceutical and therapeutic purposes. However,
liposome sterilization as well as their industrial manufacturing remain challenging. Supercritical carbon dioxide
is an innovative technology that can potentially overcome these limitations. The aim of this study was to optimize
a one-(...)
Liposome, Supercritical carbon dioxide, Green process, Quality by design, Production, Sterilization, One-step process, Encapsulation
ARTICLE
Antiulcer Effect of Aqueous Ethanolic Extracts of Pseudocedrela kotschyi (Schweinf) Harms (Meliaceae) and Ximenia americana L. (Olacaceae)
Delma, E. T., Ouédraogo, M., Ouédraogo, A. S., Nikiema, A. W., Abdoulaye Gambo, M., Ramde, N., Youl, E. N.H ., Sanou-Lamien A , Lompo O M, Guissou, P. I.
Purpose
This study aimed to provide pharmacological evidence of Pseudocedrela kotschyi and Ximenia americana in preventing or healing peptic ulcers claimed by traditional healers in Burkina Faso.
Methods
The trunk bark of Pseudocedrela kotschyi and the roots bark of Ximenia americana (Olacaceae) were macerated in mixed ethanol/water (80:20)(...)
Pseudocedrela kotschyi Ximenia americana aqueous ethanolic extract antiulcer antioxidant
ARTICLE
Evaluation de la capacité de gestion des médicaments expérimentaux par les pharmacies hospitalières des centres hospitaliers universitaires au Burkina Faso.
TARNAGDA Grissoum, OUEDRAOGO Moussa, SOMBIE Bavouma Charles, ZONGO Soumaila , OUEDRAOGO Salfo , OUEDRAOGO Henri Gautier, DRABO K. Maxime et SEMDE Rasmané
La recherche clinique, étape majeure de l’innovation thérapeutique, fait l’objet d’une intense compétition internationale. Les centres hospitaliers universitaires (CHU) sont sélectionnés pour réaliser les essais cliniques suivant des critères opérationnels. Il s’agit de satisfaire à un certain nombre de normes internationalement admis pour êtr(...)
Pharmacie hospitalière, médicament expérimental