Publications (416)
ARTICLE
Plasma levels of interleukin-18 and interleukin-12 in Plasmodium falciparum malaria
Lucia Malaguarnera, Salvatore Pignatelli, Maria Musumeci, Jacques Simporè, Salvatore Musumeci
Interleukin (IL)-18 produced primarily by mononuclear phagocytes synergizes with IL-12 for interferon-gamma production from T, B and natural killer cells. It has been also demonstrated that, in Plasmodium falciparum malaria, IL-18 could have an immunoregulatory function. The aim of this study was to detect the plasma levels of IL-12 and IL-18,(...)
interleukin-12, interleukin-18, Plasmodium falciparum, cytokines, immunorégulation, enfants, malaria, réponse immunitaire
ARTICLE
Mother-child transmission of hepatitis B virus in Ouagadougou, Burkina Faso.
D. Ilboudo, A. Sawadogo, J. Simporé
A prospective study was conducted during July-September 1999 of 299 pregnant women (aged 15-43 years; mean age 25.3 years), attending a medical centre in Ouagadougou, Burkina Faso, to determine the incidence of mother-child transmission of hepatitis B virus (HBV). The presence of HBV antigens was tested for by enzyme immunoassay. The infants o(...)
Transmission mère-enfant, virus de l’hépatite B, Ouagadougou, Burkina Faso, hépatite virale
ARTICLE
Increased levels of interleukin-12 in Plasmodium falciparum malaria: correlation with the severity of disease
Lucia Malaguarnera, Rosa Maria Imbesi, Salvatore Pignatelli, Jacques Simporè, Mariano Malaguarnera, Salvatore Musumeci
Interleukin (IL)-12, produced by mononuclear phagocytes, activates the T-helper 1 (Th1) cells and helps, as a mediator, the innate immune response to intracellular microbes. In Plasmodium falciparum infection, this proinflammatory cytokine has immunoregulatory functions with effects on the immune response to the blood stage of disease, but als(...)
interleukin-12, Plasmodium falciparum, cytokines, immunité, enfants, paludisme, sévérité, immunorégulation
ARTICLE
Modification in the frequency of Hb C and Hb S in Burkina Faso: an influence of migratory fluxes and improvement of patient health care
Jacques Simporé, Salvatore Pignatelli, Sergio Barlati, Salvatore Musumeci
The incidence of hemoglobinopathies (Hb C and Hb S) is relatively high in West Africa. In order to calculate the gene frequency of these hemoglobinopathies, 6619 students from 23 local schools in Ouagadougou, Burkina Faso, West Africa, and 2582 individuals living in five villages near Ouagadougou, all situated in Savanna, were studied. As expe(...)
hémoglobine C, hémoglobine S, hémoglobinopathie, Burkina Faso, flux migratoires, santé publique, génétique des populations, prévention secondaire, drépanocytose
ARTICLE
Biological and clinical presentation of patients with hemoglobinopathies attending an urban hospital in Ouagadougou: confirmation of the modification of the balance between Hb S and Hb C in Burkina Faso
Jacques Simporé, Salvatore Pignatelli, Sergio Barlati, Salvatore Musumeci
The incidence of hemoglobinopathies (Hb C and Hb S) is relatively high in West Africa. In order to characterize the clinical phenotypes of these hemoglobinopathies 10,166 subjects were studied for suspected hemoglobinopathies at the Laboratory of the Centre Medical Saint Camille (CMSC), Ouagadougou, Burkina Faso. A high rate of Hb SC (6.49%) a(...)
hémoglobine S, hémoglobine C, hémoglobinopathie, Burkina Faso, drépanocytose, Hb SC, Hb SS, prévention secondaire, génétique des populations
ARTICLE
Confirmation of the potential usefulness of two human beta globin pseudogene markers to estimate gene flows to and from sub-Saharan Africans
Bianca Maria Ciminelli, Fiorenza Pompei, Michela Relucenti, J. Koji Lum, Jacques Simporé, Gabriella Spedini, Cristina Martínez-Labarga, Miguel G. Pardo
Two polymorphic sites, -107 and -100 with respect to the "cap" site of the human beta globin pseudogene, recently discovered in our laboratory, turned out to have an ethnically complementary distribution. The first site is polymorphic in Europeans, North Africans, Indians (Hindu), and Oriental Asians, and monomorphic in sub-Saharan Africans. C(...)
pseudogène bêta-globine, polymorphisme génétique, flux génétiques, Afrique subsaharienne, populations humaines, admixture, marqueurs génétiques, Ethiopie, Afrique de l’Ouest
ARTICLE
Haemoglobin C protects against clinical Plasmodium falciparum malaria
Modiano D, Luoni G, Sirima BS, Simporé J, Verra F, Konaté A, Rastrelli E, Olivieri A, Calissano C, Paganotti GM, D'Urbano L, Sanou I, Sawadogo A, Modiano G, Coluzzi M
Abstract Haemoglobin C (HbC; β6Glu→ Lys) is common in malarious areas of West Africa, especially in Burkina Faso 1, 2. Conclusive evidence exists on the protective role against severe malaria of haemoglobin S (HbS; β6Glu→ Val) heterozygosity 3, whereas conflicting results for the HbC trait have been reported 4, 5, 6, 7, 8, 9, 10 and no epidemi(...)
Haemoglobin C, Beta-globin gene mutation, Plasmodium falciparum, Severe malaria, Parasitaemia
ARTICLE
Plasma chitotriosidase activity in beta-thalassemia major: a comparative study between Sicilian and Sardinian patients
R. Barone, G. Bertrand, J. Simporè, M. Malaguarnera, S. Musumeci
Background: Chitotriosidase is a functional chitinase secreted by activated macrophages, which is extremely increased in plasma of patients with Gaucher disease (beta-glucocerebrosidase deficiency). Recently, we found that chitotriosidase plasma levels were increased to a variable extent in Sicilian patients with beta-thalassemia major. The ai(...)
chitotriosidase, bêta-thalassémie majeure, surcharge en fer, macrophages activés, Sicile, Sardaigne, activité enzymatique plasmatique, étude comparative, pathologie hématologique
ARTICLE
HLA class I in three West African ethnic groups: genetic distances from sub-Saharan and Caucasoid populations
D. Modiano, G. Luoni, V. Petrarca, B. Sodiomon Sirima, M. De Luca, J. Simporé, M. Coluzzi, J. G. Bodmer, G. Modiano
Fulani of Burkina Faso (West Africa) are a particularly interesting ethnic group because of their lower susceptibility to Plasmodium falciparum malaria as compared to sympatric populations, Mossi and Rimaibé. Moreover, the occurrence of a Caucasoid component in their genetic make-up has been suggested on the basis of their physical traits and(...)
HLA classe I, Fulani, Mossi, Rimaibé, Burkina Faso, résistance au paludisme, distance génétique, Plasmodium falciparum, ethnogénétique, ARMS-PCR
ARTICLE
Plasma homocysteine concentrations in a healthy population living in Burkina Faso
Jacques Simporè, Salvatore Pignatelli, Sergio Barlati, Mariano Malaguarnera, Salvatore Musumeci
Background: The low circulating levels of homocysteine observed in a South African black population have been associated with a low occurrence of coronary heart disease.
Objective: The aim of this study was to determine whether the observation of reduced homocysteine levels in South African black subjects is valid in a black population living(...)
homocysteine, cysteine, Burkina Faso, cardiovascular risk, diet, ethnic differences
ARTICLE
Effectiveness of forced rehydration and early re-feeding in the treatment of acute diarrhoea in a tropical area
S. Pignatelli, J. Simporè, M. Ruggieri, S. Musumeci
Background: The administration of oral re-hydration solution (ORS) via continuous infusion through a nasogastric (NG) tube and early refeeding facilitates delivery in hospitalised children and the return back home.
Design: the observation was made during a one-year stage in the Camillian Medical Centre (CMC) of Ouagadougou in Burkina Faso.(...)
diarrhée aiguë, réhydratation forcée, alimentation précoce, réhydratation orale, nasogastrique, enfants, Burkina Faso, médecine tropicale, traitement de la déshydratation