Publications (441)
ARTICLE
Epidemiology of antibiotic resistance in Burkina Faso.
J. Simpore, B. Zeba, D. Karou, D. Ilboudo, S. Pignatelli, O. G. Nacoulma, S. Musumeci
Burkina Faso (West Africa) is a tropical country with a high incidence of infectious diseases. The uncontrolled use of antibiotics against bacterial pathogens has given rise to the emergence of antibiotic resistance in this country. The aims of this study were. (i) to determine the prevalences of the most important pathogenic bacteria, isolate(...)
Antibiotic resistance, Burkina Faso, Escherichia coli, bacterial pathogens, epidemiology
ARTICLE
S100B concentration in colostrums of Burkinabe and Sicilian women
Maria Musumeci, Pasqua Betta, Emanuela Magro, Teresa Isaia, Jacques Simporé, Domenico M. Romeo, Salvatore Musumeci
The aim of this study is to determine the S100B concentration in colostrums of 51 Burkinabe and 30 Sicilian women, still living in their countries, and in case of a difference to search for its explanations, considering also ethnic differences.The concentration of S100B, in colostrums of the first three days from the delivery, was assessed wit(...)
S100B protein, colostrum, Burkinabe women, Sicilian women, lactation, newborns, brain development, ethnicity, immunoluminometric assay, early postnatal adaptation
ARTICLE
Haemoglobin S and haemoglobin C: 'quick but costly' versus 'slow but gratis' genetic adaptations to Plasmodium falciparum malaria
David Modiano, Germana Bancone, Bianca Maria Ciminelli, Fiorenza Pompei, Isa Blot, Jacques Simporé, Guido Modiano
Haemoglobin S (HbS; beta6Glu-->Val) and HbC (beta6Glu-->Lys) strongly protect against clinical Plasmodium falciparum malaria. HbS, which is lethal in homozygosity, has a multi-foci origin and a widespread geographic distribution in sub-Saharan Africa and Asia whereas HbC, which has no obvious CC segregational load, occurs only in a small area(...)
Haemoglobin S, Haemoglobin C, Malaria, Plasmodium falciparum, Genetic adaptation, Burkina Faso, HbS, HbC, Mossi population, Evolutionary genetics
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Sida acuta Burm. f.: a medicinal plant with numerous potencies
SD Karou, WMC Nadembega, DP Ilboudo, D Ouermi, M Gbeassor, C De Souza, J Simpore
Sida acuta is shrub belonging to Malvaceae family. The plant is widely distributed in the subtropical regions where it is found in bushes, in farms and around habitations. Surveys conducted in indigenous places revealed that the plant had many traditional usages that varied from one region to another. The most cited illnesses are fever, headac(...)
Ethnomedicine, medicinal plants, natural substances
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Methylenetetrahydrofolate reductase gene polymorphisms in Burkina Faso: impact on plasma fasting homocysteine and after methionine loading test
Andrea Angius, Jacques Simporé, Ivana Persico, Alessandro Sassu, Dionigio Antonio Prodi, Salvatore Musumeci
In Burkina Faso the levels of plasma homocysteine (Hcy) are lower and the methionine loading tests suggest a more effective Hcy metabolism. The polymorphisms of methylenetetrahydrofolate reductase (MTHFR) showed a relevant difference in the allele frequencies of T MTHFR-677 in young and in old subjects, while the allele frequency of C MTHFR-12(...)
MTHFR gene polymorphism, Homocysteine, Methionine loading test, Burkina Faso, Genetic epidemiology, Plasma biomarkers
ARTICLE
Mother-to-child transmission of hepatitis B virus, in Ouagadougou, Burkina Faso
Andrea Angius, Jacques Simpore, Ivana Persico, Alessandro Sassu, Dionigio Antonio Prodi, Salvatore Musumeci
In Burkina Faso the levels of plasma homocysteine (Hcy) are lower and the methionine loading tests suggest a more effective Hcy metabolism. The polymorphisms of methylenetetrahydrofolate reductase (MTHFR) showed a relevant difference in the allele frequencies of T MTHFR-677 in young and in old subjects, while the allele frequency of C MTHFR-12(...)
Methylenetetrahydrofolate reductase, gene polymorphisms, homocysteine, methionine loading test, Burkina Faso
ARTICLE
Human Immunodeficiency Virus Type-1 and cytokines in colostrum from HIV-infected mothers in Burkina Faso
Maria Musumeci, Grazia Maria Palano, Piero Castronuovo, Virginio Pietra, Jacques Simpore, Salvatore Musumeci
Background:ThecolostrumofHIV-infectedmotherscontainsahighnumberofHIVcopiesandisconsideredhighlyinfectious.Furthermoreitcontainslargenumbersofmacrophageandothermononuclearcellsthatareknowntoincorporatevirus.WhilepreventionprotocolsinWesterncountriessuggesttheinterruptionofbreastfeeding,atleastforthefirstfewmonthsoflife,thispractice is not advis(...)
HIV, colostrum, Burkina Faso, viral load, cytokines, IL-18, IL-16, IL-12, TGF-beta1, TGF-beta2, mother-to-child transmission (MTCT)
ARTICLE
Haemoglobin C and S in natural selection against Plasmodium falciparum malaria: a plethora or a single shared adaptive mechanism?
F. Verra, G. Bancone, P. Avellino, I. Blot, J. Simporé, D. Modiano
Conclusive evidence exists on the protective role against clinical Plasmodium falciparum malaria of Haemoglobin S (beta 6Glu-->Val) and HbC (HbC; beta 6Glu-->Lys), both occurring in sub-Saharan Africa. However, the mechanism/s of the protection exerted remain/s debated for both haemoglobin variants, HbC and HbS. Recently, an abnormal display o(...)
Haemoglobin S, Haemoglobin C, Plasmodium falciparum, Malaria, Natural selection, PfEMP1, Cytoadherence, Immunity, Variant surface antigens, Burkina Faso
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Prevalence of rotavirus, adenovirus and enteric parasites among pediatric patients attending Saint Camille Medical Centre in Ouagadougou
Ouermi Djeneba, Karou Damintoti, Ilboudo Denise, Nadembega W. Marie Christelle, Pietra Virgilio, Belem Adrien, Simpore Jacques, Kabre Gustave, Pignatelli Salvatore, Sawadogo Laya
The present study carried out in the Saint Camille Medical Centre of Ouagadougou and related to the prevalence of Rotaviruses, Adenoviruses and enteric parasites infections among HIV-seropositive and HIV-seronegative children allowed to include 66 children aged from 2 to 60 months presenting acute diarrhea. The results revealed that 10.60% wer(...)
Rotavirus, Adenovirus, Enteric parasites, Pediatric diarrhea, HIV, Burkina Faso
ARTICLE
beta-Endorphin concentration in colostrums of Burkinabe and Sicilian women
Maria Neve Ombra, Maria Musumeci, Jacques Simporé, Grazia Maria Palano, Salvatore Musumeci
Objective: Endorphins (EPs) present in human colostrum may be relevant for immediate postnatal fetal adaptation because this compound is involved in stress response and adaptation mechanisms. Endorphin levels in human colostrum are two-fold greater than corresponding maternal plasma levels; however, the high endorphin levels in human milk decr(...)
Beta-endorphin, Colostrum, Burkinabe women, Sicilian women, Lactation, Newborn adaptation, Stress response, Labor stage II, Immunoreactive material
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The effects of spiruline on the immune functions of HIV-infected undernourished children
Jacques Simporé, Salvatore Pignatelli, Salvatore Musumeci
Background: Malnutrition is a public health problem in the entire world, particularly in the developing countries. The effect of Spiruline supplement in the weight recovery of HIV-negative and HIV-infected undernourished children has been largely demonstrated. The aim of this study is to determine the effect of Spiruline on the immune status o(...)
Spiruline, CD4 lymphocytes, undernourished children, HIV
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Prevalence of human herpes virus-8 and hepatitis B virus among HIV seropositive pregnant women enrolled in the Mother-to-Child HIV Transmission Prevention Program at Saint Camille Medical Centre in Burkina Faso
Denise Ilboudo, Damintoti Karou, Wendyame M. C. Nadembega, Aly Savadogo, Ouermi Djeneba, Salvatore Pignatelli, Virginio Pietra, Augustin Bere, Jacques Simporé, Alfred S. Traoré
The aims of this research are: i) to evaluate the prevalence of HHV-8, HBV and HIV among pregnant women, ii) to determine the percentage of these co-infections and iii) to estimate the frequency of the mother-to-child transmission of HIV among HBV and HHV-8 positive mothers. Thus, 379 pregnant women attending ante-natal consultation in Saint C(...)
HIV, HHV-8, Hepatitis B Virus, Co-infection, Mother-to-child transmission, Pregnant women, Burkina Faso
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Effective program against mother-to-child transmission of HIV at Saint Camille Medical Centre in Burkina Faso
J. Simporé, V. Pietra, S. Pignatelli, D. Karou, W. M. C. Nadembega, D. Ilboudo, F. Ceccherini-Silberstein, W. N. Ghilat-Avoid-Belem, M. C. Bellocchi, N. Saleri, M. J. Sanou, C. M. Ouedraogo, J. B. Nikiema, V. Colizzi, C. P. Perno, F. Castelli, S. Musumeci
The present research was aimed to prevent mother-to-child transmission of HIV; to use RT-PCR in order to detect, 6 months after birth, infected children; and to test the antiretroviral resistance of both children and mothers in order to offer them a suitable therapy. At the Saint Camille Medical Centre, 3,127 pregnant women (aged 15-44 years)(...)
Mother-to-child transmission, HIV, Antiretroviral therapy, Nevirapine, Resistance mutations, Burkina Faso, RT-PCR
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Glucose-6-phosphate dehydrogenase deficiency and sickle cell disease in Burkina Faso
Jacques Simporé, Denise Ilboudo, Karou Damintoti, Luc Sawadogo, Maria Esposito, Scott Binet, Henri Nitiema, Paul Ouedraogo, Salvatore Pignatelli, Jean-Baptiste Nikiema
Where malaria is endemic, there is an unexpected association between haemoglobinopathies and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency. Their coexistence in a patient with sickle cell disease (SCD) can lead to hemolytic anemia, hemoglobinuria, sepsis, renal failure and vaso-occlusive attacks (VOA). The aim of this research was to d(...)
Glucose-6-phosphate dehydrogenase deficiency, Sickle cell disease, Burkina Faso, Hemolytic anemia, Genetic traits, Vaso-occlusive attacks
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Factors predicting uptake of voluntary counselling and testing in a real-life setting in a mother-and-child center in Ouagadougou, Burkina Faso
Salvatore Pignatelli, Jacques Simpore, Virginio Pietra, Laurent Ouedraogo, Ghislaine Conombo, Nuccia Saleri, Cecilia Pizzocolo, Giuseppina De Iaco, Francois Tall, Adama Ouiminga, Giampiero Carosi, Francesco Castelli
Objective: To identify factors predicting uptake of voluntary HIV counselling and testing in pregnant women.
Methods: All pregnant women receiving ante-natal group health education at St Camille Medical Center, Ouagadougou, Burkina Faso from 1 May 2002 to 30 April 2004 were offered voluntary HIV counselling and testing. If they consented, t(...)
Voluntary counselling and testing, HIV, Burkina Faso, prevention, uptake, maternal health