Publications (441)
ARTICLE
Knowledge, attitudes and practice (KAP) regarding newborn feeding modalities in HIV-infected and HIV-uninfected pregnant women in sub-Saharan Africa: a multicentre study
L. R. Tomasoni, M. Galli, S. Declich, V. Pietra, F. Croce, S. Pignatelli, M. Fabiani, J. Simporé, M. Mabilia, E. O. Ayella, C. Caracciolo, G. Russo, G. Guaraldi, M. N. Gambirasio, V. Vullo, F. Castelli
Exclusive formula feeding, exclusive breastfeeding (EBF) with early weaning or the administration of antiretroviral therapy to lactating mothers and/or to breastfed newborns may lower postnatal HIV transmission. The aim of this study was to assess mothers' knowledge, attitudes and practice (KAP) on lactation in various real-life settings in su(...)
KAP, allaitement, VIH, femmes enceintes, Afrique sub-saharienne, EBF, prévention transmission postnatale
ARTICLE
Characterization of HIV-1 genotypes and antiretroviral drug-resistance mutations among patients in Burkina Faso
T S Kagone, H Hien, N Meda, P S Diagbouga, A Sawadogo, J Drabo, M Peeters, L Vergne, E Delaporte, C De Souza, M Gbeassor, J Simpore
The purposes of this study were: (1) to describe the genetic variability of HIV strains found in Burkina Faso, (2) to characterize non-B HIV strains mutation profiles selected by ARVs and (3) to detect possible resistances induced by ARV drugs. From 30 October 2002 to 20 November 2003, 132 HIV 1-positive patients taking Highly Active Antiretro(...)
HIV-1, genotypes, antiretroviral resistance, Burkina Faso, CRF02_AG, CRF06_cpx, HAART, polymorphism
ARTICLE
An ethnobotanical study of antimalarial plants in Togo Maritime Region
K Koudouvo, D S Karou, K Kokou, K Essien, K Aklikokou, I A Glitho, J Simpore, R Sanogo, C De Souza, M Gbeassor
Background: Malaria continues to be of great concern in Togo, as it accounts for high mortality rates, principally in children. Although plant-based medicines are the only means in major malarious regions of the country, still very little is known about the medicinal plants and medical practices of the indigenous people.
Objective: The pres(...)
Ethnobotany, antimalarial plants, traditional medicine, Togo, malaria, decoction, fidelity level, indigenous knowledge
ARTICLE
In vitro antiplasmodial activity of crude extracts from Togolese medicinal plants
Koffi Koudouvo, Simplice D Karou, Denise P Ilboudo, Kouami Kokou, Kodjo Essien, Kodjo Aklikokou, Comlan de Souza, Jacques Simpore, Mensavi Gbéassor
Objective: To investigate the antimalarial effect of a few plants in Togo folk medicine.
Methods: After ethnobotanical survey, Opilia celtidifolia, Pavetta corymbosa (P. corymbosa) and Tamarindus indica (T. indica) were selected for screening. In vitro antimalarial tests were performed on crude extracts against fresh clinical isolates of Pl(...)
Antiplasmodial, Plasmodium falciparum, plantes médicinales togolaises, activité in vitro, alkaloïdes
ARTICLE
Développement et validation d’une méthode quantitative de dosage par Chromatographie Liquide à Haute Performance Ultra-violet (CLHP-UV) de l’artémisinine dans Artemisia annua cultivé au Bénin
Hippolyte GANSE, Fernand GBAGUIDI, Taofiki AMINOU, Hermine ZIME, Mansourou MOUDACHIROU, Joëlle QUETIN-LECLERCQ
Artemisia annua, espèce de la famille des asteraceae est une plante dont les feuilles contiennent une
lactone sesquiterpénique appelée artémisinine qui est efficace contre toutes les souches de parasites
responsables du paludisme. Cette étude nous a permis de développer et de valider une méthode de
Chromatographie : la méthode de Chromatogr(...)
CLHP-UV, artémisinine, artemisia annua
ARTICLE
In vitro anti Mycobacterium tuberculosis H37Rv activity of Lannea acida A. Rich from Burkina Faso
L Ouattara, J Koudou, D S Karou, L Giacò, G Capelli, J Simpore, M Fraziano, V Colizzi, A S Traore
The cytotoxic and anti-Mycobacterium tuberculosis H37Rv activities of hydro-alcoholic extract of Lannea acida A. Rich (Anacardiaceae) were assessed. The cytoxicity evaluation was carried out on THP1 monocytoid cell line (after 24 h at 1; 5 and 10 microg mL(-1)) and showed only a slight modification of lactate dehydrogenase (LDH) release. The r(...)
Mycobacterium tuberculosis, Lannea acida, activité antimycobactérienne, cytotoxicité, extrait hydroalcoolique
ARTICLE
Strain-transcending Fc-dependent killing of Plasmodium falciparum by merozoite surface protein 2 allele-specific human antibodies
Janine Stubbs, Sope Olugbile, Balam Saidou, Jacques Simporé, Giampietro Corradin, Antonio Lanzavecchia
It is widely accepted that antibody responses against the human parasitic pathogen Plasmodium falciparum protect the host from the rigors of severe malaria and death. However, there is a continuing need for the development of in vitro correlate assays of immune protection. To this end, the capacity of human monoclonal and polyclonal antibodies(...)
Plasmodium falciparum, MSP2, anticorps, Fcγ récepteurs, phagocytose, inhibition des parasites, immunité, vaccin paludique
ARTICLE
Anthropological features of the CFTR gene: Its variability in an African population
Bianca Maria Ciminelli, Cristina Bombieri, Cinzia Ciccacci, Francesca Belpinati, Fiorenza Pompei, Roberta Maselli, Jacques Simporé, Pier Franco Pignatti, Guido Modiano
Background: The CFTR gene (Cystic Fibrosis conductance Transmembrane Regulator) is the gene responsible for Cystic Fibrosis, the most common severe autosomal recessive disease in Europeans. It has been extensively explored in several European and European-derived populations, but poorly studied in the other major human groups.
Aim: To chara(...)
CFTR, polymorphisme, génétique africaine, SNP, sélection génétique, Mossi, Afrique de l’Ouest, fibrose kystique
ARTICLE
Impact of maternal HAART on the prevention of mother-to-child transmission of HIV: results of an 18-month follow-up study in Ouagadougou, Burkina Faso
Seni Kouanda, Halima Tougri, Mireille Cisse, Jacques Simpore, Virginio Pietra, Boukare Doulougou, Gautier Ouedraogo, Charlemagne Marie Ouedraogo, Robert Soudre, Blaise Sondo Mots-clés
Mother-to-child transmission remains the main cause of global pediatric HIV infections, especially in sub-Saharan Africa. Many interventions based on single-dose antiretroviral therapy have been implemented to reduce the mother-to-child transmission of HIV. In resource-limited settings, highly active antiretroviral therapy (HAART) has only bee(...)
HAART, transmission mère-enfant, VIH, prévention, suivi à 18 mois, Burkina Faso
ARTICLE
Towards the complete eradication of mother-to-child HIV/HBV coinfection at Saint Camille Medical Centre in Burkina Faso, Africa
Denise Ilboudo, Jacques Simpore, Djeneba Ouermi, Cyrille Bisseye, Tani Sagna, Silvia Odolini, Fabio Buelli, Virginio Pietra, Salvatore Pignatelli, Charlemagne Gnoula, Jean-Baptiste Nikiema, Salvatore Musumeci
The coinfection of HIV and hepatitis B virus (HBV) and their vertical transmission constitute a public health problem in sub-Saharan countries of Africa. The objectives of this research are: i) identify the pregnant women that are coinfected by HIV and HBV at Saint Camille Medical Centre; ii) use three antiretroviral drugs (zidovudine, nevirap(...)
Co-infection VIH-HBV, transmission mère-enfant, traitement antirétroviral, PCR, Burkina Faso, Saint Camille Medical Centre
ARTICLE
[Evolution of antibiotic-resistance Staphylococcus aureus in Saint Camille Medical Centre in Ouagadougou]
Simplice D Karou, M C W Nadembega, B Zeba, D P Ilboudo, D Ouermi, S Pignatelli, V Pietra, M Gbeassor, C De Souza, Jacques Simpore
Background: Monitoring the antibiotic resistance of microorganisms in a specific geographic area can be useful in developing new approaches to first-intention antibiotherapy.
Objective: The purpose of this study was to describe the evolution of resistance of Staphylococcus aureus to antibiotics routinely used at Saint Camille Medical Centre(...)
Staphylococcus aureus, résistance aux antibiotiques, beta-lactamines, antibiogramme, Ouagadougou, Burkina Faso
ARTICLE
Genetic variation in human HBB is associated with Plasmodium falciparum transmission
Gouagna LC, Bancone G, Yao F, Yameogo B, Dabiré KR, Costantini C, Simpore J , Ouedraogo JB, Modiano D.
Genetic factors are known to have a role in determining susceptibility to infectious diseases 1, 2, although it is unclear whether they may also influence host efficiency in transmitting pathogens. We examine variants in HBB that have been shown to be protective against malaria 3 and test whether these are associated with the transmission of t(...)
HBB, Plasmodium
ARTICLE
Incidence of tuberculosis after HAART initiation in a cohort of HIV-positive patients in Burkina Faso
M. Dembélé, N. Saleri, A.C.C. Carvalho, T. Saouadogo, A.D. Hien, I. Zabsonre, S.T. Koala, J. Simporé, A. Matteelli
Objective: To determine the incidence rates of tuberculosis (TB) after the initiation of highly active antiretroviral treatment (HAART).
Methods: We conducted a retrospective cohort study on four human immunodeficiency virus (HIV) treatment centres in Ouagadougou, Burkina Faso. TB incidence was measured at different intervals after HAART in(...)
Tuberculose, VIH, HAART, incidence, Burkina Faso, CD4, IMC, épidémiologie, soins cliniques
ARTICLE
Antiretroviral (ARV) Therapy in Resource Poor Countries: What do we Need in Real Life?
Francesco Castelli, Virginio Pietra, Ismael Diallo, Richard F. Schumacher, Jacques Simporé
Significant progresses have been made in the last 5 years towards the ultimate goal to provide universal access to care for all HIV/AIDS patients needing antiretroviral treatment in resource-poor countries. However, many barriers are still to be overcome, including () cost of care for the individual, () stigma, () lack of qualified human resou(...)
ARV, VIH, accès aux soins, pays en développement, obstacles, infrastructures, pédiatrie, ruralité, formation, prévention, politique de santé, médicaments de 3e ligne
ARTICLE
Isolation of a tannic acid-degrading Streptococcus sp. from an anaerobic shea cake digester
L.W. Nitiema, D. Dianou, J. Simporé, S.D. Karou, P.W. Savadogo, A.S. Traoré
An anaerobic digester fed with shea cake rich in tannins and phenolic compounds rich-shea cake and previously inoculated with anaerobic sludge from the pit of a slaughterhouse, enabled six months acclimatization of the bacteria to aromatic compounds. Afterwards, digester waste water samples were subject to successive culture on media with 1 g(...)
Tannic acid, Streptococcus, digestion anaérobie, shea cake, gallic acid, bactéries dégradant les tanins, phénoliques, fermentation, bioconversion, pH optimal, microbiologie environnementale