Publications (441)
ARTICLE
Seroprevalence and incidence of transfusion-transmitted infectious diseases among blood donors from regional blood transfusion centres in Burkina Faso, West Africa
Bolni Marius Nagalo, Cyrille Bisseye, Mahamoudou Sanou, Kisito Kienou, Yacouba K. Nebié, Alice Kiba, Honorine Dahourou, Siaka Ouattara, Jean Baptiste Nikiema, Rémy Moret, Jean Didier Zongo, Jacques Simpore
Background and objective: The high prevalence of numerous transfusion-transmitted infectious diseases such as HIV, HBV, HCV and syphilis in sub-Saharan Africa affects blood safety for transfusion recipients. The aim of this study was to evaluate the prevalence and incidence of transfusion-transmissible infectious diseases among blood donors in(...)
Seroprevalence; Incidence; Blood donors; Transfusion-transmitted infections; HIV; HBV; HCV; Syphilis; Burkina Faso
ARTICLE
Understanding the interactions between artemisinin and cyclodextrins: spectroscopic studies and molecular modeling)
Hermine Zime-Diawara • Georges Dive • Géraldine Piel • Mansourou Moudachirou • Michel Frederich • Joëlle Quetin-Leclercq • Brigitte Evrard
Artemisinin extracted from Artemisia annua L.
proved to be currently, with its derivatives, the most effective
drugs against simple and severe malaria, and is also effective
on the chloroquine-resistant forms. The advantageous effect
of some cyclodextrins (CDs) on artemisinin solubilization
was demonstrated by different authors. The prese(...)
Artemisinin, Cyclodextrins, Non-inclusion complexes, Solubilization, Molecular modeling
ARTICLE
Formulation of oral pharmaceutical dosage forms containing crude extracts of Artemisia Annua
H. Zimé-Diawara, F. Gbaguidi, J. Gbenou, A. Laleye, R. Semde, I. Some, B. Sinsin, M. Moudachirou, J. Quetin-Leclercq, B. Evrard.
Artemisia annua is an asiatic plant with curative properties against malaria,
containing artemisinin. This active compound, and its derivatives are the last few
antimalarial drugs that remain effective against multidrug resistant strains of
Plasmodium falciparum. But they are very expensive and not accessible to poor
African countries.
Th(...)
Herbal medicinal products, Pharmaceutical dosage forms, drugs made with plants.
ARTICLE
Ethnobotanical study of medicinal plants used in the management of diabetes mellitus and hypertension in the Central Region of Togo
Simplice Damintoti Karou, Tchadjobo Tchacondo, Micheline Agassounon Djikpo Tchibozo, Saliou Abdoul-Rahaman, Kokou Anani, Koffi Koudouvo, Komlan Batawila, Amegnona Agbonon, Jacques Simpore, Comlan de Souza
Context: The Tem tribe in the Central Region of Togo is a population with an extensive knowledge of medicinal plants. However, little is known about their medical practices, principally the use of plants in the management of diabetes mellitus (DM) and hypertension (HTN).
Objective: The present study documented the indigenous medicinal plant(...)
Diabetes mellitus; Hypertension; Medicinal plants; Ethnobotany; Traditional healers; Togo; Herbal medicine
ARTICLE
An engineered Plasmodium falciparum C-terminal 19-kilodalton merozoite surface protein 1 vaccine candidate induces high levels of interferon-gamma production associated with cellular immune responses to specific peptide sequences in Gambian adults naturally exposed to malaria
C Bisseye, L M Yindom, J Simporé, W D Morgan, A A Holder, J Ismaili
The 19-kDa C-terminal region of merozoite surface protein 1 (MSP1(19)), a major blood stage malaria vaccine candidate, is the target of cellular and humoral immune responses in humans naturally infected with Plasmodium falciparum. We have previously described engineered variants of this protein, designed to be better vaccine candidates, but th(...)
Plasmodium falciparum, MSP1(19), vaccine, interferon-gamma, cytokines, T helper cells, malaria, peptides
ARTICLE
Effectiveness of the Regular Implementation of the Mother to Child Transmission Plus (MTCT-Plus) Program in Burkina Faso, West Africa
Fabio Buelli, Virginio Pietra, Richard Fabian Schumacher, Jacques Simpore, Salvatore Pignatelli, Francesco Castelli and the ESTHER-Brescia Study Group
Since the 90s, many developing countries have introduced health strategies aimed at reducing Mother-to-Child transmission rate of HIV. These strategies (PMTCT – Prevention of Mother-to-Child Transmission) are based on (i) adequate counselling for HIV voluntary testing during antenatal care visits, (ii) single dose or a short antiretroviral the(...)
MTCT-plus, VIH, transmission mère-enfant, Burkina Faso, antirétroviraux, santé familiale, nutrition, HAART
ARTICLE
Hemoglobins S and C interfere with actin remodeling in Plasmodium falciparum-infected erythrocytes
Marek Cyrklaff, Cecilia P. Sanchez, Nicole Kilian, Cyrille Bisseye, Jacques Simporé, Friedrich Frischknecht, Michael Lanzer
The hemoglobins S and C protect carriers from severe Plasmodium falciparum malaria. Here, we found that these hemoglobinopathies affected the trafficking system that directs parasite-encoded proteins to the surface of infected erythrocytes. Cryoelectron tomography revealed that the parasite generated a host-derived actin cytoskeleton within th(...)
hemoglobin S, hemoglobin C, Plasmodium falciparum, actin remodeling, infected erythrocytes
ARTICLE
[Prevalence and risk factors associated with infection by human immunodeficiency virus, hepatitis B virus, syphilis and bacillary pulmonary tuberculosis in prisons in Burkina Faso]
E A Diendéré, H Tiéno, R Bognounou, D D Ouédraogo, J Simporé, R Ouédraogo-Traoré, J Drabo
This purpose of this study was to determine prevalences and risk factors associated with infection by human immunodeficiency virus, hepatitis B Virus, syphilis and bacillary pulmonary tuberculosis in prisons in Burkina Faso. From February 20 to March 20, 2009, 300 prisoners over 18 years of age held in Ouagadougou were selected to take part in(...)
HIV; HBV; syphilis; tuberculosis; prison; prevalence; Burkina Faso; risk factors
ARTICLE
[Epidemiology, characterization of genotypes of human papillomavirus in a population of women in Ouagadougou]
C M R Ouedraogo, F W Djigma, C Bisseye, T Sagna, M Zeba, D Ouermi, S D Karou, V Pietra, F Buelli, N W Ghilat-Avoid-Belem, K Sanogo, J Sempore, R Moret, S Pignatelli, J-B Nikiema, J Simpore
Objectives: This work was carried out in order to determine the prevalence of different HPV genotypes in a population of women attending gynecological consultation.
Material and methods: From May to June 2010, cervical samples were obtained from 300 women attending gynecological consultation in two health centers in Ouagadougou. The strains(...)
Human papillomavirus; HPV genotypes; Epidemiology; Women; Ouagadougou; Gynecological consultation; PCR; Cervical infection
ARTICLE
Antimicrobial, antiplasmodial, haemolytic and antioxidant activities of crude extracts from three selected Togolese medicinal plants
Simplice D. Karou, Tchadjobo Tchacondo, Lassina Ouattara, Kokou Anani, Aly Savadogo, Amegnona Agbonon, Mossaclok Ben Attaia, Comlan de Souza, Mohsen Sakly, Jacques Simpore
Abstract
Objective: To investigate the antioxidant, antimicrobial, antiplasmodial, acute toxicity and haemolytic activities of methanolic extracts of three plants. Phytochemical analysis to determine the phenolic contents was also carried out.
Methods: The 2,2-diphenyl-1-picryl-hydrazyl (DPPH) free radical scavenging, NCCLS broth microdilu(...)
Antimicrobial, antiplasmodial, haemolytic, antioxidant, methanolic extracts, Togolese medicinal plants, phytochemical analysis
ARTICLE
Seroprevalence of human immunodeficiency virus, hepatitis B and C viruses and syphilis among blood donors in Koudougou (Burkina Faso) in 2009
Nagalo MB, Sanou M, Bisseye C, Kaboré MI, Nebie YK, Kienou K, Kiba A, Dahourou H, Ouattara S, Zongo JD, Simpore J.
Background The high prevalence of numerous transfusion-transmitted infectious diseases such as human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis in sub-Saharan Africa affects the safety of blood for recipients. This study was undertaken with the aim of determining the seroprevalence of HIV, HCV,(...)
transfusion, blood donors, HBV, HCV, Burkina Faso
ARTICLE
Enteric parasites prevalence at Saint Camille Medical Centre in Ouagadougou, Burkina Faso
Simplice Damintoti Karou, Drissa Sanou, Djeneba Ouermi, Salvatore Pignatelli, Virginio Pietra, Remy Moret, Jean Baptiste Nikiema, Jacques Simpore
Objective: To assess the prevalence of parasitic infections among patients attending Saint Camille Medical Centre and to estimate co-parasitic infections rates.
Methods: From January to December 2009, stool samples were collected from 11 728 persons, aged from five months to 72 years and suffering from gastroenteritis. After macroscopic des(...)
Parasitic infections, intestinal parasites, co-infection, Giardia intestinalis, Burkina Faso, hygiene education
ARTICLE
[Molecular diagnosis of acquired human immunodeficiency virus (HIV) in pooled plasma from blood donors at the Regional Blood Transfusion Center in Ouagadougou, Burkina Faso]
B M Nagalo, C Bisseye, M Sanou, Y K Nebié, A Kiba, K Kienou, J D Zongo, J Simporé
Study objectives: The aim of this pilot study was to investigate the use of viral genome diagnosis of HIV-1 infection in blood donors in the regional blood transfusion center in Ouagadougou, Burkina Faso.
Methodology: This prospective study was carried out from August to December 2009 at the regional blood transfusion center in Ouagadougou(...)
HIV-1, RT-PCR, blood donors, Burkina Faso, molecular diagnosis, transfusion safety
ARTICLE
Nutritional and Hematological Recovery of Severely Malnourished Children with New Flour Formulas Developed at Ouagadougou (Burkina Faso)
W.R. Compaoré, P.A. Nikièma, A. Savadogo, H.I.N. Bassole, J. Mouecoucou, S. Pignatelli, J. Simporé, S.A. Traoré
A longitudinal study was carried out, which tested the efficacy of severe malnutrition recovery with Misola and two experimental flours produced with local products (seeds of Moringa oleifera and Cucurbita maxima, pulps of Adansonia digitata and Parkia biglobosa), supplemented with Zea mays (F1) or Pennisetum glaucum (F2). A total of 187 sever(...)
Formulated flours, growth and development, infants
ARTICLE
Validation, transfer and measurement uncertainty estimation of an HPLC–UV method for the quantification of artemisinin in hydro alcoholic extracts of Artemisia annua L.
Hermine Zime Diawara, Fernand Gbaguidia, Brigitte Evrard, Joëlle Quetin Leclercq, Mansourou Moudachirou, Benjamin Debrus, Philippe Hubertd, Eric Rozet
Malaria is the world’s most important parasitic infection with 500 millions cases annually and almost 2
millions death per year. This disease is more present in Sub-Saharan Africa where 90% of the infections
are found. Artemisinin and its semi synthetic derivatives (artemether, artesunate) have actually the most
powerful activity on malaria(...)
Method transfer, Measurement uncertainty, Method validation, Artemisia annua, Hydro alcoholic extracts