Publications (375)
ARTICLE
Strain-transcending Fc-dependent killing of Plasmodium falciparum by merozoite surface protein 2 allele-specific human antibodies
Janine Stubbs, Sope Olugbile, Balam Saidou, Jacques Simporé, Giampietro Corradin, Antonio Lanzavecchia
It is widely accepted that antibody responses against the human parasitic pathogen Plasmodium falciparum protect the host from the rigors of severe malaria and death. However, there is a continuing need for the development of in vitro correlate assays of immune protection. To this end, the capacity of human monoclonal and polyclonal antibodies(...)
Plasmodium falciparum, MSP2, anticorps, Fcγ récepteurs, phagocytose, inhibition des parasites, immunité, vaccin paludique
ARTICLE
Anthropological features of the CFTR gene: Its variability in an African population
Bianca Maria Ciminelli, Cristina Bombieri, Cinzia Ciccacci, Francesca Belpinati, Fiorenza Pompei, Roberta Maselli, Jacques Simporé, Pier Franco Pignatti, Guido Modiano
Background: The CFTR gene (Cystic Fibrosis conductance Transmembrane Regulator) is the gene responsible for Cystic Fibrosis, the most common severe autosomal recessive disease in Europeans. It has been extensively explored in several European and European-derived populations, but poorly studied in the other major human groups.
Aim: To chara(...)
CFTR, polymorphisme, génétique africaine, SNP, sélection génétique, Mossi, Afrique de l’Ouest, fibrose kystique
ARTICLE
Impact of maternal HAART on the prevention of mother-to-child transmission of HIV: results of an 18-month follow-up study in Ouagadougou, Burkina Faso
Seni Kouanda, Halima Tougri, Mireille Cisse, Jacques Simpore, Virginio Pietra, Boukare Doulougou, Gautier Ouedraogo, Charlemagne Marie Ouedraogo, Robert Soudre, Blaise Sondo Mots-clés
Mother-to-child transmission remains the main cause of global pediatric HIV infections, especially in sub-Saharan Africa. Many interventions based on single-dose antiretroviral therapy have been implemented to reduce the mother-to-child transmission of HIV. In resource-limited settings, highly active antiretroviral therapy (HAART) has only bee(...)
HAART, transmission mère-enfant, VIH, prévention, suivi à 18 mois, Burkina Faso
ARTICLE
[Evolution of antibiotic-resistance Staphylococcus aureus in Saint Camille Medical Centre in Ouagadougou]
Simplice D Karou, M C W Nadembega, B Zeba, D P Ilboudo, D Ouermi, S Pignatelli, V Pietra, M Gbeassor, C De Souza, Jacques Simpore
Background: Monitoring the antibiotic resistance of microorganisms in a specific geographic area can be useful in developing new approaches to first-intention antibiotherapy.
Objective: The purpose of this study was to describe the evolution of resistance of Staphylococcus aureus to antibiotics routinely used at Saint Camille Medical Centre(...)
Staphylococcus aureus, résistance aux antibiotiques, beta-lactamines, antibiogramme, Ouagadougou, Burkina Faso
ARTICLE
Towards the complete eradication of mother-to-child HIV/HBV coinfection at Saint Camille Medical Centre in Burkina Faso, Africa
Denise Ilboudo, Jacques Simpore, Djeneba Ouermi, Cyrille Bisseye, Tani Sagna, Silvia Odolini, Fabio Buelli, Virginio Pietra, Salvatore Pignatelli, Charlemagne Gnoula, Jean-Baptiste Nikiema, Salvatore Musumeci
The coinfection of HIV and hepatitis B virus (HBV) and their vertical transmission constitute a public health problem in sub-Saharan countries of Africa. The objectives of this research are: i) identify the pregnant women that are coinfected by HIV and HBV at Saint Camille Medical Centre; ii) use three antiretroviral drugs (zidovudine, nevirap(...)
Co-infection VIH-HBV, transmission mère-enfant, traitement antirétroviral, PCR, Burkina Faso, Saint Camille Medical Centre
ARTICLE
Genetic variation in human HBB is associated with Plasmodium falciparum transmission
Gouagna LC, Bancone G, Yao F, Yameogo B, Dabiré KR, Costantini C, Simpore J , Ouedraogo JB, Modiano D.
Genetic factors are known to have a role in determining susceptibility to infectious diseases 1, 2, although it is unclear whether they may also influence host efficiency in transmitting pathogens. We examine variants in HBB that have been shown to be protective against malaria 3 and test whether these are associated with the transmission of t(...)
HBB, Plasmodium
ARTICLE
Incidence of tuberculosis after HAART initiation in a cohort of HIV-positive patients in Burkina Faso
M. Dembélé, N. Saleri, A.C.C. Carvalho, T. Saouadogo, A.D. Hien, I. Zabsonre, S.T. Koala, J. Simporé, A. Matteelli
Objective: To determine the incidence rates of tuberculosis (TB) after the initiation of highly active antiretroviral treatment (HAART).
Methods: We conducted a retrospective cohort study on four human immunodeficiency virus (HIV) treatment centres in Ouagadougou, Burkina Faso. TB incidence was measured at different intervals after HAART in(...)
Tuberculose, VIH, HAART, incidence, Burkina Faso, CD4, IMC, épidémiologie, soins cliniques
ARTICLE
Antiretroviral (ARV) Therapy in Resource Poor Countries: What do we Need in Real Life?
Francesco Castelli, Virginio Pietra, Ismael Diallo, Richard F. Schumacher, Jacques Simporé
Significant progresses have been made in the last 5 years towards the ultimate goal to provide universal access to care for all HIV/AIDS patients needing antiretroviral treatment in resource-poor countries. However, many barriers are still to be overcome, including () cost of care for the individual, () stigma, () lack of qualified human resou(...)
ARV, VIH, accès aux soins, pays en développement, obstacles, infrastructures, pédiatrie, ruralité, formation, prévention, politique de santé, médicaments de 3e ligne
ARTICLE
Isolation of a tannic acid-degrading Streptococcus sp. from an anaerobic shea cake digester
L.W. Nitiema, D. Dianou, J. Simporé, S.D. Karou, P.W. Savadogo, A.S. Traoré
An anaerobic digester fed with shea cake rich in tannins and phenolic compounds rich-shea cake and previously inoculated with anaerobic sludge from the pit of a slaughterhouse, enabled six months acclimatization of the bacteria to aromatic compounds. Afterwards, digester waste water samples were subject to successive culture on media with 1 g(...)
Tannic acid, Streptococcus, digestion anaérobie, shea cake, gallic acid, bactéries dégradant les tanins, phénoliques, fermentation, bioconversion, pH optimal, microbiologie environnementale
ARTICLE
Stratégie d’utilisation des substances naturelles dans la prise en charge des personnes vivant avec le VIH : expérience du Burkina Faso
J. B. Nikiéma, K. Djierro, J. Simporé et al.
Au Burkina Faso, les personnes vivant avec le VIH (PvVIH) ont régulièrement recours à des substances naturelles pour traiter certaines infections opportunistes. C’est ainsi que le suc des feuilles fraîches de Mitracarpus scaber Zucc. ex Schult. & Schult. f. (Rubiaceae) et de Senna alata (L.) Roxb. (Fabaceae) sont utilisés comme antimycosiques.(...)
VIH, Burkina Faso, traitement antirétroviral, plantes médicinales, médecine naturelle, médicaments
ARTICLE
Aetiology of Acute Gastro-Enteritis in Children at Saint Camille Medical Centre, Ouagadougou, Burkina Faso
J. Simpore, D. Ouermi, D. Ilboudo, A. Kabre, B. Zeba, V. Pietra, S. Pignatelli, J.B. Nikiema, G.B. Kabre, S. Caligaris, F. Schumacher, F. Castelli
The present study aims at identifying the infectious agents responsible for child Acute Gastro-Enteritis (AGE) in Ouagadougou. From May 5 2006 to June 22 2008, 648 children aged from 2 to 41 months, with at least an average of 3 loose stools per day have been enrolled for coproculture, parasitology and virology test. Among them, 34 (5.25%) wer(...)
salmonella, E. coli, EPEC, Giardia intestinalis, rotavirus, diarrhoea, acute gastro-enteritis
ARTICLE
Medicinal plants used in traditional medicine in the centre east region of Burkina Faso
J.M.K. Ky, P. Zerbo, C. Gnoula, J. Simporé, J.B. Nikiema, J. Millogo-Rasolodimby
The present research focused on the inventory and the use of plants in traditional medicine for the treatment of diseases in this area. The method was based on ethnobotanical surveys with semi-directing interview, conducted from November 2006 to December 2007 among a sample of 50 people aged between 40 and 80 years and very experienced in trad(...)
Plantes médicinales, médecine traditionnelle, ethnobotanique, Burkina Faso, maladies gastro-intestinales, paludisme, pharmacopée vétérinaire, ressources génétiques végétales
ARTICLE
Epidemiology and prognostic factors for sickle cell retinopathy in Ouagadougou (Burkina Faso)
J.W. Diallo, O. Sanfo, I. Blot, N. Meda, P. Sawadogo, A. Ouedraogo, J. Simporé
Introduction: The frequency of sickle cell disease varies from 5% to 20% in Africa.
Patients and method: This retrospective study investigated 173 patients in an ambulatory setting from August 2000 to July 2006. The study included 98 women and 75 men, aged 15-62 years, with a mean age of 26.7 years.
Results: Only 89 patients (71 SC and 1(...)
rétinopathie drépanocytaire, facteurs pronostiques, épidémiologie, Ouagadougou, Burkina Faso
ARTICLE
Antimicrobial resistance and serotype distribution of Streptococcus pneumoniae strains causing childhood infection in Burkina Faso
Leonard C. Bere, Jacques Simpore, Simplice D. Karou, Boukaré Zeba, Augustin P. Bere, Elizabeth Bannerman, Jacques Bille, Mireille Dosso
In Burkina Faso, a Western African country, reports on pneumococci carriage, resistance patterns and serotypes are inconsistent. The present study was conducted in order to evaluate these parameters. Thus 860 nasopharyngeal swabs were collected from children attending vaccination centers for pneumococci isolation, identification and serotype d(...)
Streptococcus pneumoniae, résistance antimicrobienne, sérotypes, enfants, Burkina Faso, antibiotiques
ARTICLE
Reversible reduction of nevirapine plasma concentrations during rifampicin treatment in patients coinfected with HIV-1 and tuberculosis
Alberto Matteelli, Nuccia Saleri, Paola Villani, Victor Bonkoungou, Anna Cristina C Carvalho, Seni Kouanda, Marie J Sanou, Jacques Simporé, Laura Monno, Giampiero Carosi, Mario Regazzi, Mathurin Dembele
Background: Nevirapine (NVP) plasma levels are reduced in patients receiving rifampicin (RFM) for tuberculosis (TB) treatment. We determined variations over time of the pharmacokinetic parameters of NVP in patients who receive RFM.
Methods: HIV-1-infected patients with CD4+ T-lymphocyte count <or=100 cells per microliter and TB diagnosis re(...)
nevirapine, rifampicin, pharmacokinetics, HIV-1, tuberculosis, plasma concentrations, AUC, combined therapy