Publications (155)
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Development of an in vitro Endotoxin Test for Monoolein–Water Liquid Crystalline Gel for Use as an Implant
Moustapha Ouédraogo, Rasmané Semdé, Touridomon Issa Some, Rasmata Ouédraogo, Viviane Henschel, Brigitte Evrard, Jacques Dubois, Karim Amighi and Innocent P Guissou
Purpose: Drugs that are administered by parenteral route must be apyrogenic. The aim of this study was to develop an in vitro endotoxin test for liquid crystalline gels for use as implants, using a monoolein–water liquid crystalline gel as a model. Methods: The gel-clot technique was used. The gel was dissolved first in isopropyl myristate, an(...)
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Home-based practices of complementary foods improvement are associated with better height-for-age Z score in 12-23 months-old children from a rural district of Bu...
H.Z. Ouédraogo, Laetitia Ouedraogo Nikiema, Touridomon Issa Some, Jean Sakande, M Dramaix-Wilmet, and P Donnen
Repositioning nutrition is central to development. Childcare practices, which include feeding practices, appear in the conceptual framework of malnutrition. The objective of this study was to analyze the nutritional status of young children in relation to feeding practices. This cross-sectional, community-based study was conducted in the rural(...)
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Provitamin A carotenoid content of dried fermented cassava flour: The effect of palm oil addition during processing
Inocent Gouado , Adelaide Demasse Mawamba , Ruphine Solange Meyimgo Ouambo , Issa Touridomon Some and Tchouanguep Mbiapo Félicité
Vitamin A deficiency is a public health problem in developing countries. Cassava is a major staple food for most Africans. Most often, it is processed into dried fermented cassava (commonly called gari) to limit post harvest losses. The white or yellow type of gari can be obtained without or with the addition of red palm oil respectively. Howe(...)
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In vivo Biocompatibility and Toxicity Assessment of a Gentamicin-Loaded Monoolein Gel Intended to Treat Chronic Osteomyelitis
Moustapha Ouédraogo, Melanie Sanou, Norbert Ramde, Olga Goumbri, Touridomon Issa Some, Rasmané Semdé University of Ouagadougou View profile Rasmata Ouédraogo Universite joseph ki zerbo Ouagadougou View profile Innocent P. Guissou, Viviane Henschel, Brigitte Evrard, Karim Amighi and Jacques Dubois
[en] Biocompatibility and preliminary toxicity of a novel gentamicin-loaded monoolein gel (implant) intended for the local treatment of chronic osteomyelitis were investigated in mice. The mice, randomly allotted in 3 groups of 10, received respectively a single dose (0.05 mL) of normal saline, monoolein and the gel by subplantar injection. Cl(...)
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In vitro biocompatibility and genotoxicity assessment of a gentamicin-loaded monoolein gel intended to treat of chronic osteomyelitis
Moustapha Ouédraogo, Nacoulma Eric, Rasmané Semdé, Touridomon Issa Some, Innocent Pierre Guissou, Viviane Henschel, Brigitte Evrard, Karim Amighi and Jacques Dubois
[en] The aim of the study was to assess in vitro the biocompatibility and the genotoxicity of a gentamicin-loaded monoolein gel intended to treat of chronic osteomyelitis. Indeed, we are developing biodegradable implants based on monoolein and gentamicin. The results of formulations, physico-chemical characterization of the formulated implants(...)
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Preventive effect on superoxide anion production of four winephenolics molecules administered with a moderate dose in a metabolic syndrome murine model.
J. Azay-Milhau, E. Youl, T. Sutra, C. Oiry, M. Moréna, J. L. Bessone, R. Magous, J. P. Cristol, G. Cros, P. L. Teissèdre
We demonstrated that phenolics extracts from skin and grapes extracts with an ingestion dose of 21,4 mg/kg Body Weight (corresponding to a moderate daily consumption of 500 mL polyphenols richest red wine) for the fructose fed rats (a metabolic syndrome model) were able to correct overproduction of ROS (Reactive Oxygen Species), the surexpress(...)
Oenology, polyphenols, delphinidin (anthocyanine), gallic acid (phenolic acid), resveratrol (stilbene), catechin (tanin)
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Automédication dans le traitement de l’accès palustre: étude auprès de clients d’officines pharmaceutiques privées de la ville de Ouagadougou, Burkina Faso
L T Ouédraogo, Touridomon Issa Somé, M DiarraI et P Guissou
Afin de contribuer à un débat national sur le changement de protocole de traitement du paludisme simple au Burkina Faso, nous avons réalisé une étude transversale descriptive auprès de 397 clients de 45 officines privées de la ville de Ouagadougou.Nous avons noté que la chloroquine (39, 3%), la sulfadoxine-pyriméthamine (24, 4%) et l'artémisin(...)
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Self-medication in the treatment of acute malaria: study based on users of private health drug stores in Ouagadougou, Burkina Faso
L T Ouédraogo, Touridomon Issa Somé, M DiarraI et P Guissou
In order to contribute to the national debate on the change of protocol of the simple forms of malaria treatment in Burkina Faso, we conducted a transversal descriptive study among 397 private pharmacies users in Ouagadougou. The aims of the study were:-making an inventory of the antimalarials and signs which led to self-medication;-identifyin(...)
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Preventive Effects of Nutritional Doses of Polyphenolic Molecules on Cardiac Fibrosis Associated with Metabolic Syndrome: Involvement of Osteopontin and Oxidative Stress
THIBAULT SUTRA,†,‡ CATHERINE OIRY, JACQUELINE AZAY-MILHAU, ESTELLE YOUL, RICHARD MAGOUS, PIERRE-LOUIS TEISSE`DRE, JEAN-PAUL CRISTOL AND GE ́RARD CROS
We previously showed that grape extracts enriched in different polyphenolic families were similarly able to prevent reactive oxygen species (ROS) production, although having differential effects on various features of metabolic syndrome when administered at a dose of 21 mg/kg to the fructose (60%)-fed rat (a model of metabolic syndrome). In th(...)
Polyphenols; fructose; rat; collagen I; osteopontin; ROS
ARTICLE
Preliminary Clinical Assessment of a Gentamicin-Loaded Monoolein Gel Intended to Treat Chronic Osteomyelitis
Moustapha Ouédraogo, Christophe S. Da, Innocent S. Nacoulma, Hamado Kafando, Rasmané Semdé, Touridomon Issa Some, Rasmata Ouédraogo, Innocent P. Guissou, Jacques Dubois and Karim Amighi,
The aim of this study was to perform a preliminary clinical assessment of efficacy and safety of a biodegradable gentamicin-loaded monoolein gel. An open single dose, one treatment study including 19 patients with chronic osteomyelitis caused by a microorganism sensitive to gentamicin was conducted. After surgical curettage of the infected bon(...)
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Monoolein–water liquid crystalline gels of gentamicin as bioresorbable implants for the local treatment of chronic osteomyelitis: in vitro characterization
Moustapha Ouédraogo , Rasmané Semdé , Issa Touridomon Somé , Rasmata Traoré/Ouédraogo, , Innocent Pierre Guissou , Viviane Henschel and Jacques Dubois
To maximize the efficacy of chronic osteomyelitis antibiotherapy while reducing antibiotic systemic toxicity, as well as time and costs of hospitalizations, it has been thought that monoolein–water gels incorporating gentamicin sulfate could be used as local, bioresorbable, and sustained-release implants. For this purpose, four formulations we(...)
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Carotenoids Content of Some Locally Consumed Fruits and Yams in Cameroon
Gouado Inocent, Aba Richard Ejoh, Touridomon Issa Some, Florian J Schweigert, Tchouanguep M.F
Vitamin A deficiency constitutes a public health problem in Cameroon. Data on provitamin A content of fruits locally consumed are scarce. To solve this nutritional problem, it is important to promote the consumption of yellow/orange fruits or green leafy vegetables which are rich sources of provitamin A. In order to achieve this, the carotenoi(...)
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Influence of malaria on the serum levels of vitamin A, zinc and calcium of children in Douala-Cameroon
Gouado Inocent, Lehman Leopold Gustave, Some Issa T., Mbouyap Yolande, PankouiMfonkeu Joel Bertand, Ejoh Aba Richard and Tchouanguep Mbiapo Felicité
Malaria is an endemic parasitic disease that prevails particularly in warm tropical regions of the world. Micronutrient malnutrition such as vitamin A and iron deficiencies which is a public health problem in Cameroon is usually highly prevalent in malaria endemic areas. Characterizing the relationship between micronutrient status (vitamin A,(...)
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Influence of malaria on the serum levels of vitamin A, zinc and calcium of children in Douala-Cameroon
Gouado Inocent, A. O. Adebiyi, Leopold G Lehman,Touridomon Issa Some, Yolande Mbouyap, Joel Bertand Pankoui Mfonkeu, Aba Richard Ejoh, Felicité Tchouanguep Mbiapo
Malaria is an endemic parasitic disease that prevails particularly in warm tropical
regions of the world. Micronutrient malnutrition such as vitamin A and iron deficiencies which
is a public health problem in Cameroon is usually highly prevalent in malaria endemic
areas. Characterizing the relationship between micronutrient status(...)
Malaria, vitamin A, zinc, calcium
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The positive impact of red palm oil in school meals on vitamin A status: study in Burkina Faso
Zeba Augustin, Yves Martin-Prevel, Touridomon Issa Some and Hélène Delisle
Vitamin A (VA) deficiency is widespread in sub-Saharan Africa and school-age children are a vulnerable group. In Burkina Faso, the production and consumption of red palm oil (RPO) is being promoted as a food supplement for VA. The objective of the study was to assess the impact on serum retinol of adding RPO to school lunch in two test zones o(...)
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