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Publications Scientifiques
11 publications trouvées
ARTICLE

A Non-Coding Fc Gamma Receptor Cis-Regulatory Variant within the 1q23 Gene Cluster Is Associated with Plasmodium falciparum Infection in Children Residing in Burkina Faso

Jules Cretin, Mathieu Adjemout, Christelle Dieppois, Frederic Gallardo, Magali Torres, Zachary Merard, Serge Aimé Sawadogo, Christophe Picard , Pascal Rihet, Pascale Paul
Antibodies play a crucial role in activating protective immunity against malaria by interacting with Fc-gamma receptors (FcγRs). Genetic variations in genes encoding FcγRs can affect immune cell responses to the parasite. In this study, our aim was to investigate whether non-coding variants that regulate FcγR expression could influence the prevalence of Plasmodium falciparum infection. Through bioinformatics approaches, we selected expression quantitative trait loci (eQTL) for FCGR2A, FCGR2B, FCGR2C, FCGR3A, and FCGR3B genes encoding FcγRs (FCGR), in whole blood. We prioritized two regulatory variants, rs2099684 and rs1771575, located in open genomic regions. These variants were identified using RegVar, ImmuNexUT, and transcription factor annotations specific to immune cells. In addition to these, we genotyped the coding va...
ARTICLE

An expression quantitative trait locus of Fc gamma receptor genes is associated with antimalarial IgG responses and infection levels in Burkinabe families

Christelle Dieppois, Mathieu Adjemout, Jules Cretin, Frederic Gallardo, Magali Torres, Christophe Picard, Serge Aimé Sawadogo, Pascal Rihet, Pascale Paul.
Bakground: The interaction between antibodies and Fcy receptors (FcyRs) plays a critical role in regulating immune responses to Plasmodium falciparum. Polymorphisms in genes encoding FcyRs influence the host's capacity to control parasite infection. The study investigates whether noncoding variants influencing FcyR expression are associated with antimalarial immunization and infection traits. Methodes: We utilized qQTL databases and functional annotations to identify noncoding variants, specifically rs1771575, rs2099684 and rs6700241, within the FCGR gene cluster. In addition, we examined the coding variants rs1801274 (p.His167Arg) and rs1050501 (p.Ile231Thr) which affect the affinity of FcYRlla and FcyRIIb for IgG. These variants were genotyped in 163 individuals from Burkinabe families. Family-based linear mixed regression and Quantitative Transmission Disequilibrium Tests (QTDT) anal...
ARTICLE

Dynamic Study and Modelling of Arsenic Removal from Groundwater Using Ferromagnetic Carbon as Fixed Bed Adsorbent in Column.

Yacouba Sanou, Nguyen Thi Thanh Phuong, Samuel Paré, Nguyen Van Phuoc
This study investigated the performance of Ferromagnetic Carbon (FC) as an effective natural adsorbent for arsenic removal from groundwater in Dong Thap Province (Vietnam). To do this, leaching fixed-bed column experiments have been carried out. The influence of operating variables affecting the process was studied, under varying operating conditions and experimental data were modelled using bed depth service time (BDST) and mass transfer approaches. Speciation studies showed that the groundwater contained 48.5% of particulate arsenic and 51.5% of soluble arsenic. Indeed, As (III) and As (V) forms represented respectively 41.9% and 58.1% in the dissolved arsenic. As removal was parametric depending such as pH, flow rate, initial As and adsorbent mass, requiring an optimization for optimum conditions When the pH increased from 3 to 11, removal of As(V) decreased from 96.5% t...
ARTICLE

FOREST MANAGEMENT AND LAND USE DYNAMICS IN THE WAKOU COMMUNAL FOREST AND DIAPANGOU SYLVOPASTORAL ZONE (BURKINA FASO)

Francoise Valea
In Burkina Faso, the degradation of forest resources has led to the implementation of strategies to preserve and restore plant formations. To this end, the Wakou communal forest (FC) and the Diapangousylvopastoral zone (ZSP), in the east of the country, have benefited from forest management. This study analyzes the impact of these management on vegetation by mapping the different land-use units. To this end, 08 Landsat images from 1989, 1999, 2009 and 2018 were processed. Field observations and data collection were used to perform a supervised classification using maximum likelihood. The results show that in the FC, the area of wooded savannah has increased significantly, rising from 1.95% in 1989 to 54.53% in 2018. Shrub savannah has decreased from 89.22% in 1989 to 42.14% in 2018. Fields have also declined, respectively from 13.55% in 1...
ARTICLE

Evaluation du risque de majoration des anomalies électrocardiographiques de repos au cours d’une épreuve d’effort chez des arbitres masculins de football du Burkina Faso

Tiama Adama, Yameogo Nobila Valentin, Gouthon Fabrice Gilchrist, Nouatin Kocou Basile, Bio Nigan Issiako, Seghda Taryetba André Arthur, Ouedraogo Kiswendsida Guy Hervé, Ouedraogo Lynda
Introduction : L’activité physique régulière est bénéfique pour la santé cardiovasculaire mais chez les sujets présentant des anomalies à l’électrocardiogramme (ECG) standard, l’effort intense peut s’avérer délétère. Le but de cette étude était de déterminer au cours d’une épreuve d’effort, le risque de majoration des anomalies ECG de repos chez des arbitres de football d’élite et de sub-élite masculins du Burkina Faso. Méthodes : Il s’est agi une étude d’intervention, réalisée avec 18 arbitres, répartis en deux groupes : groupe cas (GCA : n = 7) et groupe contrôle (GCO : n = 11) à profil ECG de repos respectivement anomal et normal. GCA et GCO ont été soumis à une épreuve d’effort maximale suivant un protocole de Bruce avancé. Les profils chronotrope et tensionnel, l’accroissement tensionnel systolique, l’électrocardiogramme d’effort, puis l’échocardiogramme ont été étudiés. La pente d’...
ARTICLE

EVALUATION DU RISQUE DE MAJORATION DES ANOMALIES ELECTROCARDIOGRAPHIQUES DE REPOS AU COURS D’UNE EPREUVE D’EFFORT CHEZ DES ARBITRES MASCULINS DE FOOTBALL DU BURKINA FASO

Tiama Adama , Yaméogo Nobila Valentin , Gouthon Fabrice Gilchrist , Nouatin Kocou Basile , Bio Nigan Issiako , Seghda Taryetba André Arthur , Ouedraogo Kiswendsida Guy Hervé , Ouedraogo Lynda
Introduction : L’activité physique régulière est bénéfique pour la santé cardiovasculaire mais chez les sujets présentant des anomalies à l’électrocardiogramme (ECG) standard, l’effort intense peut s’avérer délétère. Le but de cette étude était de déterminer au cours d’une épreuve d’effort, le risque de majoration des anomalies ECG de repos chez des arbitres de football d’élite et de sub-élite masculins du Burkina Faso. Méthodes : Il s’est agi une étude d’intervention, réalisée avec 18 arbitres, répartis en deux groupes : groupe cas (GCA : n = 7) et groupe contrôle (GCO : n = 11) à profil ECG de repos respectivement anomal et normal. GCA et GCO ont été soumis à une épreuve d’effort maximale suivant un protocole de Bruce avancé. Les profils chronotrope et tensionnel, l’accroissement tensionnel systolique, l’électrocardiogramme d’effort, puis l’échocardiogramme ont été étudiés. La pent...

Publications récentes

Article

Défis contemporains d'une souveraineté nationale: lecture croisée de quelques romans burkinabè

Pascal KOMBOIGO et Lamoussa TIAHO
Le roman burkinabè pose littéralement l’épineuse question de la recherche des voies et moyens en vue d’un réel progrès sur le continent africain en général et pour le Burkina Faso en particulier. Pour ce faire il ressort de la conscience des œuvres qui s’ouvrent à notre analyse que la dominée société textuelle romanesque est marquée par de nombreuses contre valeurs socioculturelles. Ces contre-valeurs censées être combattues par un système viable ne le sont pas car la volonté de certains actants à promouvoir les valeurs sociales et culturelles constructives se heurte malheureusement à un désordre systémique qui nourrit et entretient les contre valeurs socioculturelles. Nous nous intéressons ici à la vision du monde des auteurs dans leurs romans, de relever les défis auxquels sont confrontés les États par le biais du structuralisme et de la narratologie.
Article

Données techniques, chronologiques et historiques de la sidérurgie directe dans le Gulmu

THIOMBIANO Foniyama Elise épouse ILBOUDO
La province du Gulmu est l’une des localités ayant bénéficié raisonnablement d’investigations scientifiques sur la question de la production ancienne du fer (J.B. Kiethéga, 2009 ; F.E. Thiombiano/Ilboudo, 1991, 2010 ; O. Yougbaré, 1992 ; H. Lankoandé, 2015, 2018, 2023). Les résultats des travaux montrent un potentiel archéométallurgique conséquent. De même, l’analyse des vestiges révèle, au stade actuel des recherches, deux catégories de fourneaux selon le mode opératoire, soutenues par une variabilité de traditions techniques. Les datations radiocarbones réalisées sur les fourneaux de la région mettent en évidence des séquences chronologiques qui s’étalent du VIe au début du XXe siècle de notre ère, permettant non seulement d’apprécier l’évolution temporelle de cette activité ancestrale mais aussi d’analyser la dynamique du peuplement de la région étudiée. Pour l’...
Article

Development of a voice awareness system in local languages for maternal and child health in Burkina Faso

Lydie Simone TAPSOBA and Relwendé Aristide YAMEOGO
This paper addresses the persistent disparities in maternal and child health in developing countries, particularly in rural Burkina Faso, where linguistic and infrastructural barriers hinder access to preventive healthcare information. The study aims to design and implement an automated voice awareness system in local languages to enhance maternal health literacy. Using a mixed technological approach combining Progressive Web Applications, Interactive Voice Response, and Short Message System notifications, the system delivers personalized health messages accessible even under low-connectivity conditions. A pilot deployment at Banfora integrates community health workers to ensure local adoption. Preliminary literature review results show a 25–45% increase in prenatal consultations and vaccination adherence. The proposed framework aligns technology with health equity, contributing to Susta...
Article

Automated Detection of Tuberculosis on Chest X-rays Using Artificial Intelligence

Lydie Simone TAPSOBA, Moumouni DJIBO and Relwendé Aristide YAMEOGO
Detecting tuberculosis on X-rays remains complex and challenging for clinicians. In Burkina Faso, the scarcity of radiologists and their heavy workload increase the risk of misinterpretation, particularly in areas with high demand. To address this constraint, we have designed a comprehensive solution based on artificial intelligence, ranging from data analysis to the training of advanced deep learning models, enabling the automatic identification of tuberculosis abnormalities from chest X-rays. In this article, we present our three-step approach for tuberculosis detection, directly inspired by the clinical reasoning of the radiologist. First, we classify the images into those that are normal and those that are not. Next, we segment the images to keep only the pulmonary area. Finally, in this area, we perform a detection of tuberculosis-related anomalies.
Article

Assessment of Physicochemical Characteristics and Microbiological Quality of Fried Shrimps Sold in Rural Municipality of Loumbila

Cissé Hama, Nebié Sibiri, Zongo Oumarou, Traoré Roukiatou, Djibrine Adoum Oumar, Konwougoum Inoussa, Zingué B. A. Romaric, Tapsoba François, Sawadogo Adama, Abdelsalam Tidjani and Savadogo Aly
Shrimp is a crustacean found in marine and freshwater environments and is widely distributed throughout the world due to its nutritional and socioeconomic values. However, its chemical composition, rich in proteins and lipids, and its water content, make it an easily perishable food commodity and particularly susceptible to microbiological and physicochemical alterations. As part of the study, ten samples of fried shrimps were collected from different sales sites in Loumbila. Physicochemical characteristics and microbiological quality were assessed using standard analytical methods. TMAF loadings ranged from 0.29±0.12x106 CFU/g to 1.83±1.29x106 CFU/g. Dry matter and water content ranged from 87.23±1.25 % to 95.92±0.67 % and 4.08±0.67 % to 12.77±1.25 %, respectively. Also, acidity and pH ranged from 0.04 % to 0.12±0.01 % and 8.48±0.06 and 8.99±0.11, respectively. As for the loads of therm...
Article

Intelligent crop disease detection system using leaf image analysis with computer vision

Lydie Simone TAPSOBA, Wendolian Romain SOALLA, Nebnoma Emmanuel KIEBRE
Burkina Faso's agriculture sector faces major challenges, with annual crop losses reaching 40% due to plant diseases, affecting 2.7 million people in a situation of food insecurity. This research presents an innovative automatic plant disease detection system using computer vision, specifically developed for West African constraints. The system is based on the YOLOv11 (You Only Look Once) unified detection architecture, recognised for its optimal balance between speed and accuracy in real time, essential for mobile deployment to detect diseases in maize, tomatoes and chillies with an overall accuracy of ~99%. The image dataset from Kaggle has been validated by local agronomic expertise from INERA, ensuring the relevance of disease classes specific to the Sahelian context. The proposed architecture demonstrates superior performance to existing approaches while being optimised for mobile d...
Article

A Novel Reference Model for Intelligent and Comfortable Longitudinal Vehicle Control: Theory, Optimization, and Validation

Flavien H. Somda, Désiré Guel, Kisito K. Kaboré, Antoine Schorgen
This paper introduces a novel reference model for intelligent longitudinal vehicle control, designed to enhance both safety and passenger comfort. The proposed model dynamically adjusts the follower vehicle’s acceleration based on its penetration distance relative to the lead vehicle, ensuring smooth speed transitions and adaptive deceleration. By preventing abrupt braking, the model maintains a safe inter-vehicle distance while reducing passenger discomfort. Key contributions include an analytical derivation of the follower vehicle’s dynamics and a novel formulation of the safety distance using the Lambert W function, enabling precise parameter optimization. A dedicated optimization framework ensures compliance with safety constraints while minimizing excessive acceleration and jerk. The model’s performance is validated through numerical simulations in various driving scenarios, includi...
Article

Hepatotoxic Effects of Sildenafil Adulterated Herbal Aphrodisiacs (Attoté and Congnons-moussos), Following Chronic Exposure in Male Wistar Rats

Nomawendé Emmanuel Joachim Armel OUEDRAOGO, Basile TINDANO , Wendyam Joëlle Raymonde YOUGBARE, Elisabeth OUEDRAOGO, T. Jean Luc KABORE, Abdelaziz KOUSSOUBE, Abdoul Dramane SANA, Souleymane BENGYENDE, Balé BAYALA
The adulteration of traditional aphrodisiac formulations with phosphodiesterase type 5 inhibitors (PDE5i), particularly sildenafil, represents a significant public health concern due to the toxicological risks associated with their uncontrolled and prolonged use. This study investigated the subchronic hepatotoxic effects of two commercially available aphrodisiac preparations, called Attoté (AT) and Congnons-moussos (CM), both containing sildenafil (1 mg/gdry matter), in male Wistar rats. Animals were allocated into eight groups and received distilled water (control), pure sildenafil (5 mg/kg b.w.), and increasing doses (50, 100, and 200 mg/kg b.w.) of AT and CM by oral gavage for 90 consecutive days. Hepatic function was evaluated through serum biochemical markers such as Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), total bilirubin, albumin, total proteins, glucose,...
Article

On-station and on-farm participatory evaluation and selection of stable and high-yielding Bambara groundnut in Burkina Faso

Zakaria Kiebre, Mariam Kiebre, Romaric Kiswendsida Nanema, Fanta Reine Sheirita Tietiambou, Karim Abdou Traore, Philippe Banazaro, Veli-Matti Rokka, Hamid El Bilali , Filippo Acasto and Jacques Nanema
Introduction: Low yield is often claimed as one of the most important challenges for Bambara groundnut production in West Africa. To address the lack of high-yielding genotypes of Bambara groundnut in Burkina Faso, participatory evaluation and selection through multilocation trials is an important step to be taken. The present study aims at the participatory evaluation and selection of high-yielding and stable Bambara groundnut landraces in Burkina Faso. Methods: A BGN collection was evaluated involving 274 growers through multilocation trials, including on-station and on-farm trials. Through semi-structured interviews, the most important trait for BGN selection and the growers’ most preferred genotypes were identified. The collection was subjected to genetic stability and adaptability analysis based on the most important trait identified by growers. Results: The study hig...
Article

Prévalence et antibiorésistance des souches de Salmonella spp. et de Staphylococcus aureus isolées dans les sandwichs vendus en milieux scolaires dans la ville de Maradi (NIGER)

Abdourhamane SAHIROU, Namwin Siourimè SOMDA, Losséni DAO, Ibrahim IDDO , Edwige SOME , Ouindgueta Juste Isidore BONKOUNGOU
Cette étude a évalué la qualité microbiologique de 133 sandwichs vendus dans 21 écoles de la ville de Maradi (Niger) et déterminé le profil de résistance aux antibiotiques des souches de Salmonella spp. et de Staphylococcus aureus isolées. Les analyses ont révélé une prévalence de 8,27 % pour Salmonella spp. (11 échantillons) et de 9,77 % pour S. aureus (13 échantillons). Le profil d'antibiorésistance est alarmant : les souches de S. aureus ont montré une résistance de 100 % à de nombreux antibiotiques (pénicilline, céfoxitine, ciprofloxacine, érythromycine, tétracycline, etc.), tandis que les souches de Salmonella étaient résistantes à 90,9 % à l'azithromycine. En revanche, une bonne sensibilité a été observée pour certains antibiotiques comme l'imipénème, la gentamicine et la ceftriaxone (90,9 % de sensibilité). La présence de ces bactéries pathogènes témoigne du non-respect des bonnes...
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