Publications récentes
Article
Acute and subchronic toxicity of aqueous extracts of Combretum micranthum (G. Don) and Gardenia sokotensis (Hutch) having ethnobotanical uses in Burkina Faso
OUEDRAOGO Elisabeth,*, ZABRE Genevieve, TINDANO Basile, YOUGBARE Wendyam Jöelle Raymonde, OWONA Pascal Emmanuel, BAYALA BaléMedicinal plants are the major sources of drugs used to treat diseases. Scientific studies were performed on some plants, but few data are available on the medicinal plants used to manage bone diseases in Burkina Faso. This study was conducted to identify medicinal plants used in the treatment of osteoporosis and investigate the acute and subchronic toxicity of Combretum micranthum and Gardenia sokotensis aqueous extracts. A survey was carried out through a structured interview with traditional practitioners. Phytochemical screening was performed using a validated thin-layer chromatographic method. The acute oral toxicity study of extracts was validated at 2000 mg/kg in mice. In the subchronic toxicity, rats were orally administered 100, 200, and 400 mg/kg of each extract for 90 days. Results show sixty-one plant species divided into 33 families. C. micranthum and G. sokotensis were most...
Article
Enquête CAP (Connaissances, aptitudes, pratiques) auprès de la population et des professionnels de santé sur le noma et la santé bucco-dentaire en 2012 dans la région du Sahel, Burkina Faso
Hadissa TAPSOBA, Jocelyne Valérie GARÉ, Aissata Sané CONGO, Lamoussa Robert ZOMA, Ernest Robert TOÉntroduction. Le noma est un enjeu majeur de santé publique dans la région du Sahel au Burkina Faso. Pour lutter contre ce fléau, des acteurs se sont mobilisés pour construire un projet en s’appuyant sur l’état des connaissances de la population et des professionnels sur cette pathologie.
But de l’étude. Étude descriptive sur les connaissances, attitudes et pratiques relatives au noma et à la santé bucco-dentaire dans la région du Sahel en 2012.
Résultat. Bien que la population ne connaisse pas le terme « noma », les symptômes en sont généralement connus. Les connaissances des causes d’altération de la santé bucco-dentaire sont plus confuses. Si la population est consciente des besoins d’hygiène dentaire et du possible rôle de l’alimentation, des efforts de sensibilisation sont nécessaires. Une faille réside dans les capacités du système de santé. Les agents de santé sont insuff...
Article
Effects of Combretum micranthum against menopause-related osteoporosis based on ADMET, network pharmacology, and experimental validation
Ouedraogo Elisabeth, Owona Pascal Emmanuel, Tindano Basile, Bilanda Danielle Claude, Zabré Généviève, Tcheutchoua Carlos Yannick , Koussoubé Abdelaziz, Kaboré Tééganimbé Jean Luc , Bidingha A. Goufani Ronald, Ogunlakin Daniel Akingbolabo, Bayala BaléLow bone density is a defining feature of osteoporosis. Combretum micranthum is traditionally used in Burkina Faso against osteoporosis. This research sought to assess the effect of Combretum micranthum (AECM) on an osteoporosis model induced by ovariectomy and to conduct molecular docking and ADMET screening of the identified potentially active compounds from the AECM leaves by using in silico techniques. A pharmacology network was constructed to identify genes corresponding to active compound targets. Networks of compound targets and protein-protein interactions were constructed using Cytoscape software. To evaluate C. micranthum’s effect on the ovariectomized rats, a sham-operated group and some ovariectomized groups were treated with distilled water or with AECM and estradiol valerate. In the in silico study, the extract compounds like myricetin and rhamnazin predicted good pharmacok...
Article
Fraternal Dynamics and Academic Performance of Hearing and Deaf Learners in Inclusive Schools in Burkina Faso
Sekma Gustave Zongo, Bawala Léopold BadoloIn the Burkinabè educational context, deaf children are exposed to affective
and sensory vulnerabilities that can significantly influence their sibling relationships.
These dynamics may foster a sense of belonging and emotional regulation
or, conversely, heighten exclusion and stigmatization. This study examines
the impact of sibling anxiety on academic performance in French and
mathematics. Drawing on the theoretical frameworks of Vygotsky (1978), Bowlby
(1969), and Bronfenbrenner (2000), the study was conducted with 111 participants
(77 students, 24 parents, and 10 teachers) in the Kadiogo and Nando
regions. Research tools included the Family Drawing Test, the Sibling Relationship
Questionnaire (SRQ), interview guides, and grades from harmonized
examinations. Data were processed using regression analyses (SPSS 27) and
manual content analysis. The analyses indicate that sibli...
Article
Parasitic Contamination of Urban Surface Waters in Ouagadougou, Burkina Faso: Implications for Public Health
Wendyam Christine Tougouma, Idrissa Ouedraogo, Moustapha Nikiema, Pegdwende Abel Sorgho, Roger Ouedraogo, Fidèle Lamboni, Rimwaodo Pierre Silga, Salam Sankara, Winkom Noellie Kpoda, Awa GnemeAims: Urbanization in African cities has led to significant public health challenges, largely attributable to inadequate sanitation infrastructure. Poor surface water quality is the source of the spread of communicable diseases. This study aimed to examine parasite contamination in surface waters in the city of Ouagadougou. Study Design: A parasitological study was conducted on six water bodies in the city of Ouagadougou, from May 2023 to June 2024. Methodology: Water samples were collected during the rainy and dry seasons. A multiparameter device was used to measure the pH, temperature, electric conductivity, and total dissolved solids (TDS) of water on site. Samples were subjected to microscopic examination after the modified Bailenger method and the modified Ziehl–Neelsen technique. The prevalence of parasites was compared by site and season using a chi-squared test. The effect of phy...
Article
Floristic structure and phytosanitary condition of woody species in Razoutenga forest in Burkina Faso
Diakalya Traoré, Yacouba Ouédraogo, Fatimata Sanogo & Safiétou IlboudoThis study analyses the floristic composition and phytosanitary condition of woody species in Razoutenga forest, Burkina Faso. Using 20 randomly placed circular plots (1250 m2 each), research-ers inventoried trees ≥15 cm in diameter across 2.5 ha. The forest hosts 71 woody species from 18 genera and 9 families, with Mimosaceae, Combretaceae and Anacardiaceae being most abundant. Health assessments show 92.95% of trees are defect-free, with no desiccated crowns or dead specimens. Regeneration includes 137 juvenile plants in 20 genera. While species diversity is moderate and locally adapted, signs of anthropogenic degradation are evident. Sustainable management is urgently needed to conserve biodiversity and restore ecosystem integrity.
Article
Prevalence and molecular characterization of ESBL-producing Enterobacterales in clinical samples from the Boucle du Mouhoun region in Burkina Faso
Hiliassa Coulibaly, Dissinviel Stéphane Kpoda, Hervé Kafando, Oumar Traoré, Alix Bénédicte Kagambega, Alassane Halawen Mohamed, Robin Fréderic, Racha Beyrouthy, Dramane Ouédraogo, Oumarou Soro, Dominique Bayala, Nicolas Barro, Richard Bonnet & René DembéléBackground: Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae represent a major clinical and public health concern due to their ability to confer resistance to multiple classes of antibiotics. Data on the molecular epidemiology of ESBL-producing Escherichia coli and Klebsiella pneumoniae remain limited in many regions of Burkina Faso, particularly outside the Ouagadougou and Bobo Dioulasso. This study aimed to determine the frequency of ESBL-producing Escherichia coli and Klebsiella pneumoniae and to characterize the ESBL resistance genes circulating in the Boucle du Mouhoun region. Methods: A total of 1,845 clinical samples (urine, pus, blood, and semen) collected from patients attending two major healthcare facilities in Dédougou were processed during the study period. From these samples, 247 non-duplicate Escherichia coli and Klebsiella pneum...
Communication
Problématisation de l'extrémisme violent dans La malice des hommes de Jean Pierre Guingané
Pingdewindé Issiaka TIENDREBEOGOL’Afrique, et en particulier le Burkina Faso, est confrontée ces dernières années aux
problématiques liées au terrorisme et à l’extrémisme violent. Fort de cela, la problématique de
la violence devient un leitmotiv thématique dans les imaginaires dramaturgiques des auteurs
africains, au nombre desquels Jean-Pierre GUINGANÉ. Depuis 2015, le Burkina Faso subit
une crise marquée par des attaques terroristes multiformes, accompagnées de lourdes pertes
humaines et de dégâts considérables À travers l’esthétique de la banalisation, et dans une
tentative de « tourner la face au soleil », pour reprendre le thème de la 13ᵉ édition des
Récréâtrales du 26 octobre au 2 novembre 2024, l’un des festivals de théâtre les plus renommés
en Afrique, nous proposons d’explorer la problématique de la tolérance telle qu’elle est mise
en scène dans La malice des hommes de Jean-Pierre GUINGANÉ.
Article
Integrating Biochar to Sustain Lettuce Production in Sandy Soils of Burkina Faso Under Water-Limited Conditions
Faith Mawia Muema, Marie Sawadogo, Amadou Keita, Yohan Richardson, Firmin Sawadogo, Yacouba SanouValorization of agricultural residues into biochar for soil applications offers dual ben-efits of waste management and sustainable agriculture. However, the mechanisms governing sandy soil and lettuce response to biochar under deficit irrigation are not well understood. TheThis study evaluated the effects of biochar types on sandy soil physio-chemicalphysiochemical properties and lettuce (Lactuca sativa L.) yield at different irrigation levels. A field experiment was performed using a randomized com-plete block design with four treatments (soil only, cotton stalk biochar, cashew nut-shells biochar, and a mix of cotton stalks+ cashew nutshells biochar) and three irriga-tion regimes (100%, 80, and 60% of crop water requirements ETc) in Ouagadougou, Burkina Faso. The results showed that biochar -amended soils had consistently higher water retention and macro nutrientsmacronutrients, resulti...
Article
Optimization of Antigen Concentrations to Improve the Signal to Noise Ratio of ELISA Tests for the Detection of Anti Plasmodium falciparum Antibodies
Nicolas OUEDRAOGO, Fatimata THIOMBIANO, Oumarou OUEDRAOGO, Mireille OUEDRAOGO, Guillaume Sylvestre SANOU, Harouna SORE, Casimire Wendlamita TARAMA, François TAPSOBA, Yéri Esther HIEN, Kaba Mariama CHERIF and Aly SAVADOGOMalaria, caused by the parasite Plasmodium falciparum, remains a major public health priority in tropical regions. The Enzyme-Linked Immunosorbent Assay (ELISA) for detecting anti-Plasmodium antibodies is an essential diagnostic tool. However, its sensitivity and specificity are closely dependent on the concentration of antigens used.
This study aimed to determine the optimal antigen concentration for seven P. falciparum antigens (AMA1, MSP1, GLURP, CSP, EBA175, MSP3, and EXP1) in order to optimize the signal-to-background noise ratio of indirect ELISA tests. To achieve this, titration microplates were coated with serial dilutions of each antigen (from 2 μg/ml to 0.0625 μg/ml), incubated with patient sera, and then developed using conjugated secondary antibodies. Each antigen concentration was tested in duplicate wells (n=2), using Hyper-Immune Tanzanian (HIT) plasma at antigen-specific...