Publications (375)
ARTICLE
Haemoglobin S and C affect the motion of Maurer's clefts in Plasmodium falciparum-infected erythrocytes
Nicole Kilian, Martin Dittmer, Marek Cyrklaff, Djeneba Ouermi, Cyrille Bisseye, Jacques Simporé, Friedrich Frischknecht, Cecilia P. Sanchez, Michael Lanzer
The haemoglobinopathies S and C protect carriers from severe Plasmodium falciparum malaria. We have recently shown that haemoglobin S and C interfere with host-actin remodelling in parasitized erythrocytes and the generation of an actin network that seems to be required for vesicular protein trafficking from the Maurer's clefts (a parasite-der(...)
Plasmodium falciparum ; hémoglobine S ; hémoglobine C ; Maurer's clefts ; réseau d’actine ; paludisme ; cytosquelette ; hémoglobinopathies
ARTICLE
Rotavirus in diarrheal children in rural Burkina Faso: high prevalence of genotype G6P[6]
Johan Nordgren, Isidore Juste O Bonkoungou, Leon W Nitiema, Sumit Sharma, Djeneba Ouermi, Jacques Simpore, Nicolas Barro, Lennart Svensson
Group A rotavirus (RVA) is the most common cause of severe gastroenteritis in young children globally, and responsible for a significant number of deaths in African countries. While vaccines are available, trials have shown a lesser efficacy in Africa. One of the reasons could be the prevalence and/or emergence of unusual or novel RVA strains,(...)
Burkina Faso ; rotavirus ; diarrhée ; génotypes ; G6P[6] ; épidémiologie ; diversité génétique ; enfants
ARTICLE
In vitro Antimicrobial Activity of Some Phenolic Compounds (Coumarin and Quercetin) Against Gastroenteritis Bacterial Strains
Leon W. Nitiema, Aly Savadogo, Jacques Simpore, Dayeri Dianou and Alfred S. Traore
In this work, antibacterial activity of coumarin and quercetin were compared. An in vitro study was carried out using the following bacterial strains involved in gastroenteritis diseases by using agar diffusion method and dilution method: Escherichia coli 81nr.149 SKN541, Enterobacter aerogenes CIP 104 725, Salmonella typhimurium SKN533 and Sa(...)
Coumarin, Quercetin, gastroentérite, souches bactériennes, activité antibactérienne
ARTICLE
Epidemiology and antibiotic resistance of bacterial meningitis in Dapaong, northern Togo
Simplice D. Karou, Abago Balaka, Mitiname Bamoké, Daméhan Tchelougou, Maléki Assih, Kokou Anani, Kodjo Agbonoko, Jacques Simporé, Comlan de Souza
Objective: To assess the seasonality of the bacterial meningitis and the antibiotic resistance of incriminated bacteria over the last three years in the northern Togo.
Methods: From January 2007 to January 2010, 533 cerebrospinal fluids (CSF) samples were collected from patients suspected of meningitis in the Regional Hospital of Dapaong (n(...)
Togo ; méningite bactérienne ; ceinturon de la méningite africaine ; antibiotiques ; résistance ; épidémiologie ; saisonnalité
ARTICLE
Seroprevalence of toxoplasmosis and rubella in pregnant women attending antenatal private clinic at Ouagadougou, Burkina Faso
Laure Stella Ghoma Linguissi, Bolni Marius Nagalo, Cyrille Bisseye, Thérése S. Kagoné, Mahamoudou Sanou, Issoufou Tao, Victoire Benao, Jacques Simporé, Bibiane Koné
Objective: To evaluate the prevalence of toxoplasmosis and rubella among pregnant women at Ouagadougou in Burkina Faso.
Methods: All patient sera were tested for rubella and toxoplasmosis anti-IgG using commercial ELISA kits (Platelia™ Rubella IgG and Platelia™ Toxo IgG). The presence of anti-rubella and anti-toxoplasmosis IgM in serum samp(...)
Burkina Faso ; rubéole ; toxoplasmose ; femmes enceintes ; séroprévalence ; risque périnatal
ARTICLE
Prise en charge du VIH/sida et migrations internationales dans le district rural de Nanoro, Burkina Faso [HIV/AIDS care and international migrations in the rural district of Nanoro, Burkina Faso]
B. Autino, S. Odolini, H. Nitiema, D. Kiema, A. Melzani, V. Pietra, M. Martinetto, M. Bettinzoli, J. Simpore, G. Sulis, E. Focà, F. Castelli
West African Countries account for almost half of the estimated 20 000 000 international migrants in the continent. In the frame of the scaling up of HAART, our study aims to identify specific features and constraints of access to care for HIV migrant patients returning to Burkina Faso. From January 2007 to August 2011, the Nanoro District Hos(...)
VIH, migration, accès aux soins, HAART, Burkina Faso
ARTICLE
Emergence of unusual G6P[6] rotaviruses in children, Burkina Faso, 2009-2010
Johan Nordgren, Leon W. Nitiema, Sumit Sharma, Djeneba Ouermi, Alfred S. Traore, Jacques Simpore, Lennart Svensson
To obtain more information about rotavirus (ROTAV) genotypes in Burkina Faso, we characterized 100 ROTAVs isolated from fecal samples of children with acute gastroenteritis in the capital city of Ouagadougou, during December 2009-March 2010. Of note, 13% of the ROTAV-positive samples, including those with mixed infections, were positive for th(...)
Rotavirus; G6P[6]; Burkina Faso; children; gastroenteritis; genotype surveillance
ARTICLE
Screening Togolese medicinal plants for few pharmacological properties
Simplice D. Karou, Tchadjobo Tchacondo, Micheline Agassounon Djikpo Tchibozo, Kokou Anani, Lassina Ouattara, Jacques Simporé, Comlan de Souza
Background: Terminalia macroptera Guill. et Perr. (Combretaceae), Sida alba L. (Malvaceae), Prosopis africana Guill et Perr. Taub. (Mimosaceae), Bridelia ferruginea Benth. (Euphorbiaceae), and Vetiveria nigritana Stapf. (Asteraceae) are traditionally used in Togolese folk medicine to treat several diseases including microbial infections.
Ob(...)
Antimicrobial; antioxidant; hemolytic; phenolics.
ARTICLE
[Prevalence of intestinal parasites at Saint-Camille medical center in Ouagadougou (Burkina Faso), 1991 to 2010]
D Ouermi, D S Karou, I Ouattara, C Gnoula, V Pietra, R Moret, S Pignatelli, J B Nikiema, J Simpore
Background: Intestinal parasitoses continue to be a major public health problem in developing countries.
Objectives: This study sought to evaluate the prevalence of intestinal parasites and their coinfection rates in patients attending the Saint-Camille medical center in Ouagadougou. Methodology. This retrospective study covers the period f(...)
Burkina Faso; parasitoses intestinales; prévalence; protozoaires; helminthes; co-infections; santé publique.
ARTICLE
Seroprevalence and incidence of transfusion-transmitted infectious diseases among blood donors from regional blood transfusion centres in Burkina Faso, West Africa
Bolni Marius Nagalo, Cyrille Bisseye, Mahamoudou Sanou, Kisito Kienou, Yacouba K. Nebié, Alice Kiba, Honorine Dahourou, Siaka Ouattara, Jean Baptiste Nikiema, Rémy Moret, Jean Didier Zongo, Jacques Simpore
Background and objective: The high prevalence of numerous transfusion-transmitted infectious diseases such as HIV, HBV, HCV and syphilis in sub-Saharan Africa affects blood safety for transfusion recipients. The aim of this study was to evaluate the prevalence and incidence of transfusion-transmissible infectious diseases among blood donors in(...)
Seroprevalence; Incidence; Blood donors; Transfusion-transmitted infections; HIV; HBV; HCV; Syphilis; Burkina Faso
ARTICLE
Understanding the interactions between artemisinin and cyclodextrins: spectroscopic studies and molecular modeling)
Hermine Zime-Diawara • Georges Dive • Géraldine Piel • Mansourou Moudachirou • Michel Frederich • Joëlle Quetin-Leclercq • Brigitte Evrard
Artemisinin extracted from Artemisia annua L.
proved to be currently, with its derivatives, the most effective
drugs against simple and severe malaria, and is also effective
on the chloroquine-resistant forms. The advantageous effect
of some cyclodextrins (CDs) on artemisinin solubilization
was demonstrated by different authors. The prese(...)
Artemisinin, Cyclodextrins, Non-inclusion complexes, Solubilization, Molecular modeling
ARTICLE
Formulation of oral pharmaceutical dosage forms containing crude extracts of Artemisia Annua
H. Zimé-Diawara, F. Gbaguidi, J. Gbenou, A. Laleye, R. Semde, I. Some, B. Sinsin, M. Moudachirou, J. Quetin-Leclercq, B. Evrard.
Artemisia annua is an asiatic plant with curative properties against malaria,
containing artemisinin. This active compound, and its derivatives are the last few
antimalarial drugs that remain effective against multidrug resistant strains of
Plasmodium falciparum. But they are very expensive and not accessible to poor
African countries.
Th(...)
Herbal medicinal products, Pharmaceutical dosage forms, drugs made with plants.
ARTICLE
Ethnobotanical study of medicinal plants used in the management of diabetes mellitus and hypertension in the Central Region of Togo
Simplice Damintoti Karou, Tchadjobo Tchacondo, Micheline Agassounon Djikpo Tchibozo, Saliou Abdoul-Rahaman, Kokou Anani, Koffi Koudouvo, Komlan Batawila, Amegnona Agbonon, Jacques Simpore, Comlan de Souza
Context: The Tem tribe in the Central Region of Togo is a population with an extensive knowledge of medicinal plants. However, little is known about their medical practices, principally the use of plants in the management of diabetes mellitus (DM) and hypertension (HTN).
Objective: The present study documented the indigenous medicinal plant(...)
Diabetes mellitus; Hypertension; Medicinal plants; Ethnobotany; Traditional healers; Togo; Herbal medicine
ARTICLE
An engineered Plasmodium falciparum C-terminal 19-kilodalton merozoite surface protein 1 vaccine candidate induces high levels of interferon-gamma production associated with cellular immune responses to specific peptide sequences in Gambian adults naturally exposed to malaria
C Bisseye, L M Yindom, J Simporé, W D Morgan, A A Holder, J Ismaili
The 19-kDa C-terminal region of merozoite surface protein 1 (MSP1(19)), a major blood stage malaria vaccine candidate, is the target of cellular and humoral immune responses in humans naturally infected with Plasmodium falciparum. We have previously described engineered variants of this protein, designed to be better vaccine candidates, but th(...)
Plasmodium falciparum, MSP1(19), vaccine, interferon-gamma, cytokines, T helper cells, malaria, peptides
ARTICLE
Effectiveness of the Regular Implementation of the Mother to Child Transmission Plus (MTCT-Plus) Program in Burkina Faso, West Africa
Fabio Buelli, Virginio Pietra, Richard Fabian Schumacher, Jacques Simpore, Salvatore Pignatelli, Francesco Castelli and the ESTHER-Brescia Study Group
Since the 90s, many developing countries have introduced health strategies aimed at reducing Mother-to-Child transmission rate of HIV. These strategies (PMTCT – Prevention of Mother-to-Child Transmission) are based on (i) adequate counselling for HIV voluntary testing during antenatal care visits, (ii) single dose or a short antiretroviral the(...)
MTCT-plus, VIH, transmission mère-enfant, Burkina Faso, antirétroviraux, santé familiale, nutrition, HAART