Détails Publication
Prevalence and genotype characterization of human papillomaviruses among HIV-seropositive in Ouagadougou, Burkina Faso,
Discipline: Sciences biologiques
Auteur(s): FW Djigma, C Ouedraogo, DS Karou, T Sagna, C Bisseye, M Zeba, D Ouermi, C Gnoula, V Pietra, NW Ghilat-Avoid-Belem, K Sanogo, J Sempore, S Pignatelli, AM Ferri, J-B Nikiema, J Simpore
Auteur(s) tagués: SIMPORE Jacques
Renseignée par : DJIGMA Wendkuuni Florencia
Résumé

Background
Approximately, 15–20 of 40 HPVs that infect the female genital tract confer a high-risk of invasive cancer, thus HPVs account for 95% of cervix cancers. The objectives of this study were to: (i) estimate the prevalence of HPV infection in women infected with HIV in Ouagadougou, (ii) identify potential carcinogenic HPV strains and (iii) determine whether existing HPV vaccines match the isolated strains.
Methods
From May 2009 to April 2010, 250 HIV-infected women were included in this study. Each woman was screened for the presence of HPV and for HPV genotype using PCR/hybridization technique.
Results
Of the 250 HIV-infected women, 59.6% were infected with at least one type of HPV. High-risk HPVs were identified with the following prevalence: HPV-18 (25.0%); HPV-50′S (25.5%); HPV-30′S (20.8%); HPV-16 (4.7%); HPV-45 (3.7%). Low-risk HPVs were represented by HPV-6 (5.7%) and HPV-11 (0.9%).
Conclusion
The issue of the study showed that the existing vaccines: Gardasil and Cervarix may be used in the country although they match only HPV-16, HPV-18, HPV-6 and HPV-11. Further investigations should be continued for the establishment of vaccine that matches all genotypes circulating in the country.

Mots-clés

HPV; HIV+ Women; Burkina Faso

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