Aims
To evaluate in vitro the properties of a blend of medicinal plants called Cancerol S through its antioxidant, anti-inflammatory and cytotoxic potential on cancerous cells in culture.
Methodology
High-performance thin-film chromatography (HPTLC) and the assay test were used for phytochemical screening of Cancerol S. The antioxidant power of Cancerol s was evaluated by free radical inhibition tests (DPPH and ABTS) and the Iron III Reduction Power (FRAP). The inhibition tests of 15-LOX (15-lipoxygenase) and COX1/COX2 (cyclooxygenases) were used to evaluate the anti-inflammatory capacity of Cancerol S.
Results
The total polyphenols and flavonoids content of the extract were respectively 115.6±0.1 mg EAG/g and 43.4±0.1 mg EQ/g dry extract. The extract showed excellent antioxidant activity, with inhibition of DPPH (EC50= 8.3±0.7 μg/mL) and ABTS (EC50= 36.0±1.1 μg/mL), and also reduced ferric ion Fe3+(2.67±0.1 mmol EAA/g extract). In addition, the extract moderately inhibited 15-LOX, COX-1 and COX-2. The HeLa cell line of cervical cancer was more sensitive to Cancerol S (EC50= 84.6±5.2 μg/mL) than the prostate cancer cell line DU 145 (EC50= 140.7±7.8 μg/mL).
Conclusion
These properties give a rational basis for the use of Cancerol S in traditional medicine in Burkina Faso.

Cytotoxic; antioxidant; anti-inflammatory; Cancerol S.