Introduction
Pulmonary tuberculosis and COVID-19 have shared some similarities in term of clinical manifestations and modes of transmission. COVID-19 could increase the mortality rate of tuberculosis. Consequently, pulmonary tuberculosis and COVID-19 co-infection could be a major public health concern. The aim of this study was to establish the prevalence of pulmonary tuberculosis and COVID-19 co-infection in the city of Ouagadougou, Burkina Faso.
Method
Mycobacterium tuberculosis DNA, was detected using GeneXpert (Cepheid, USA), on the sputum of suspected pulmonary tuberculosis. Anti-SARS-CoV-2 antibodies (IgM and IgG) was detected using the Accu-Tell rapid kit (AccuBio Techn Co, Ltd kit) on the blood plasma of suspected pulmonary tuberculosis cases. SARS-CoV-2 RNA amplification was then performed using the TaqPath kit (Applied Biosystems), with the QuantStudio 5 thermocycler on nasopharyngeal swabs from patients found positive for pulmonary tuberculosis.
Results
The prevalence of pulmonary tuberculosis was 27.54%(65/236). Among tuberculosis-positive patients who accepted the COVID-19 serological test, co-infection was 12.5%(3/24). The prevalence of Mycobacterium tuberculosis resistance to rifampicin was 9.23%. Males and patients aged 40 and below were the most likely to be infected with pulmonary tuberculosis at 76.90% and 66.20% respectively. Seroprevalence of COVID-19 was 12.63%.
Conclusion
Pulmonary tuberculosis and COVID-19 co-infection was a reality in this study.

Co-infection, Tuberculosis;, COVID-19;, Mycobacterium tuberculosis;, SARS-CoV-2;, Burkina Faso.