Détails Publication
Association of DRB1*11 and DRB1*12 alleles of the HLA system with the evolution of the Hepatitis B virus infection in Burkina Faso,
Discipline: Médecine clinique
Auteur(s): Sidnooma Véronique Zongo 1 · Florencia Wendkuuni Djigma 1,2 · Albert Théophane Yonli 1,2 · Pegdwendé Abel Sorgho 1,2 · Marius Bolni Nagalo 3 · Lassina Traore 1 · Dogfounialo Somda 1,2 · Lanyo Jospin Amegnona 1 · Eugène Languie 1 · Couna Christiane Bere Some 4 · Lydie Marie Jeannette Sia 5 · Boaffi Sourabie 2· Roger Arsène Sombie 1· Abdel Karim Serme 1· Dorcas Obiri‑Yeboah 6· Jacques Simpore
Auteur(s) tagués: SOMBIÉ Arsène Roger
Renseignée par : SOMBIÉ Arsène Roger
Résumé

Background Hepatitis B Virus (HBV) infection affect all social strata of humanity and in the absence of any management, this infection has a different outcome from one infected person to another. This suggests that there are specific individual factors that influence the outcome of the pathology. Sex, immunogenetics and age of contraction of the virus have been cited as factors that influence the evolution of the pathology. In this study, we looked at two alleles of the Human Leucocyte Antigen (HLA) system to measure their possible involvement in the evolution of HBV infection.

Method and results We conducted a cohort study involving 144 individuals spread over 04 distinct stages of infection and then compared allelic frequencies in these populations. A multiplex PCR was conducted and the data obtained was analyzed using R and SPSS software. Our study revealed a predominance of HLA-DRB1*12 in our study population without, however, showing a significant difference between HLA-DRB1*11 and HLA-DRB1*12. The HLA-DRB1*12 proportion was significantly higher in chronic hepatitis B (CHB) and resolved hepatitis B (RHB) compared to cirrhosis and hepatocellular carcinoma (HCC) (p-value = 0,002). Carrying HLA-DRB1*12 has been associated with a low risk of complication of infection (CHB → cirrhosis; OR 0,33 p-value 0,017; RHB → HCC OR 0,13; p-value = 0,00,045) whereas the presence of HLA-DRB1*11 in the absence of HLA-DRB1*12 increased the risk of developing severe liver disease. However, a strong interaction of these alleles with the environment could modulate the infection.

Conclusion Our study shown that HLA-DRB1*12 is the most frequent and it’s carriage may be protective in the development of infection.

Mots-clés

Burkina Faso · HCC · Cirrhosis · HLA · DRB1 · 11 · DRB1 · 12 · HBV

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