Invasive species are known to be a threat to agriculture and biodiversity. Thus, many studies have focused on the negative ecological impacts of invasive species, while their importance to livelihoods and human well-being has received little attention. This study aimed to explore people's ethno-ecological knowledge about the invasion of Senna obtusifolia and the importance of this species in some local ethnic groups according to two climate zones in Burkina Faso. Three hundred (300) people from eight (08) ethnic groups from surrounding villages of pastoral zones in two contrast climate zones were interviewed. The survey technique was semi-structured interviews, using a previously tested semi-structured questionnaire. A Generalized Linear Model (GLM) with the Poisson distribution was performed to determine the factors that influence the ethno-ecological knowledge of people. For informants, the most important dissemination drivers are animals in the Sahelian zone and humans in the Sudanian zone. Regarding usefulness, the species is harvested by people for 08 use categories with food (100%) and construction (46%) as the most use categories. In fact, use value of Senna obtusifolia differed significantly among climatic zones, ethnic groups (P

Climatic zone, Ethnic group, Invasive species, Local knowledge, Senna obtusifolia