African histoplasmosis is rare in our country. We report a case of multifocal African histoplasmosis with peritoneal and pericardial involvement. A 27 year old man, a gold digger, consulted for disseminated papular and nodular lesions that had been evolving for 3 months. On examination, cachexia (body mass index 15.19kg/m2), cold abscesses all over the integument, umbilicated papules predominating on the face and ascites were noted. Paraclinical investigations showed neutrophilia, anaemia, hypoprotidemia, exudative ascites, pericarditis, severe pulmonary arterial hypertension, large 8-shaped yeasts of Histoplasma capsulatum var. duboisii on direct examination of the mycological specimen, confirming African histoplasmosis. Good clinical outcome was achieved with itraconazole. Severe malnutrition was probably a risk factor for dissemination of the disease

Visceral involvement, undernutrition, itraconazole