The aim of this study was to evaluate the in vitro antiplasmodial activities of four plants used intraditional medicine. Hydroethanolic extract, hydroacetonic extract and aqueous extract ofMitragyna inermis(Willd.) O. Kuntze (Rubiaceae), Combretum sericeum G. Don (Combretaceae), Alternanthera pungens H.B.and K (Amaranthaceae) and Ampelocissus grantii (Baker) Planch (Vitaceae) have been tested in vitro againstchloroquine-resistant strain (K1) and chloroquine-sensitve strain (3D7) ofPlasmodium falciparumusing pLDHassay. Aqueous extracts exhibited the best results ag ainst K1 with the 50% inhibitory concentration (IC 50)values of 0.54±0.18, 1.72±0.99, 1.54±0.04 :g/mL for respectively, M. inermis leaves, C. sericeum leaves andwhole plant of A. pungens . Hydroethanolic extract from the leaves of M. inermis gave also IC 50 value of0.87±0.10 :g/mL with 3D7. Extracts showed antiplasmodial activity against both chloroquine-sensitive andchloroquine-resistant P. falciparum strains. Our study justifies the use of these plants in traditional medicineand leads to further investigations .