West African Medicinal Plant Substances and Molecules Activities Against Viral Hepatitis B and Hepatocellular Carcinoma

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Résumé

Background:
Chronic hepatitis B virus (HBV) infection remains a major global public
health problem with devastating consequences, such as hepatocellular carcinoma. Currently, approved
treatments are limited to interferon and nucleoside/nucleotide analogues for chronic hepatitis
B and chemotherapy, radiotherapy, and surgery for cancer. Both treatments have their limitations,
making complete cure an elusive goal. Therefore, the identification of new therapeutic targets
using medicinal plants and the development of new antiviral and anticancer strategies are of
utmost importance.


Objective:
The aim of this review is to identify from the literature the substances and molecules of
West African flora involved in the fight against chronic hepatitis B and liver cancer and to provide
a summary of their mechanisms of action.


Methods:
Pubmed, HAL open science, and Google Scholar literature search engines were used to
identify medicinal plants and molecules from the West African flora.


Results:
Among West African countries, Gambia and Niger had the highest prevalence of hepatitis
B virus infection, and 09 West African countries had high rates of liver cancer. A number of
studies carried out in Mali, Benin, Senegal, and Burkina Faso enabled us to list anti-HBV and anticancer
plants, as well as a number of molecules isolated from plants found in West African regions.


Conclusion:
By offering a glimpse into the world of anti-HBV and anticancer molecules from
West Africa, this review provides valuable information to support the future development of herbal
antiviral and anticancer drugs.

Mots-clés

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