Anti-Inflammatory Activity of Extracts from Parkia biglobosa (Jacq.) R.Br. Ex G.Don. (Fabaceae-Mimosoideae) Trunk Bark

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Résumé

Background and Objective: Parkia biglobosa is used in the treatment of several inflammatory pathologies. The work aimed to study
the toxicity, anti-inflammatory, analgesic and antioxidant effects of aqueous and hydroethanolic extracts from the bark of the trunk of
Parkia biglobosa. Materials and Methods: A phytochemical study was carried out using the TLC method and the toxicity of the extracts
was evaluated. The anti-inflammatory effect of extracts was evaluated using mice paw edema-induced by carrageenan injection and ear
edema by croton oil application and these inhibitor effects against LOX and COX. The analgesic effect of the extracts was evaluated
according to the writhing test. DPPH, FRAP, ABTS and LPO methods were used to evaluate antioxidant capacity. Results: Aqueous and
hydroethanolic extracts are considered as slightly toxic substances. Extracts significantly reduced edema caused by carrageenan. At a dose
of 500 µg/ear, the extracts used reduced (more than 50%) the edema caused by the application of croton oil to the inner surface of the
ear of mice. Both extracts inhibited pro-inflammatory enzymes (LOX, COX 1 and 2) activities. Extracts exhibited antioxidant power
using four methods (DPPH, FRAP, ABTS and LPO). Conclusion: These results are scientific data that could therefore justify the use of
Parkia biglobosa trunk bark in the treatment of inflammatory diseases in traditional medicine.

Mots-clés

Parkia biglobosa, anti-inflammatory, analgesic, antioxidant, lipoxygenase, cyclooxygenase, traditional medicine