Antihypertensive, antihyperlipidemia and hepatoprotective activity of ethanolic extract of Moringa oleifera leaves

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Résumé

The ethanolic extract of Moringa oleifera(EEM) prevented and exerted curative effect on high
acute blood pressure induced by L-NAME (10mg/kg). This acute curative effect of EEM (20mg/kg) in acute high blood pressure induced by L-NAME is transitory and reversible. In the subacute hypertension induced by L-NAME (40mg/kg), oral administration of L-NAME causes an increase in blood pressure (BP) (P<0.01) after 4 weeks. Concomitant daily administration of L-NAME and captopril or L-NAME and EEM partially inhibited the increase of BP induced by L-NAME. This decrease in BP was accompanied by a decrease in heart rate (HR). The analysis of some parameters of lipid profile revealed a significant decrease in levels of triglyceride, total cholesterol and atherogenic index in animals treated preventively with ethanolic extract of the plant (200 or 400mg/kg) or captopril (20mg/kg); its was observed against by, an increase in HDL-cholesterol levels in the same groups of animals. The analysis of hepatic and renal function parameters showed a significant decrease in ALT, AST and bilirubin levels compared to animals treated with only L-NAME. Moreover, no significant differences were observed in the total creatinin, total protein and total cholesterol levels, except the group treated with extract 400mg /kg.

Mots-clés

Moringa oleifera; L-NAME; Lipid profile; ALT; AST; Bilirubin