Factors Associated with Death in Patients with Liver Cirrhosis at Tengandogo University Hospital Center

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Résumé

Introduction: Liver cirrhosis is a major public health problem in sub-Saharan
Africa, where it is often diagnosed at an advanced stage and associated with
high mortality. This study aimed to identify the factors associated with death
in patients with liver cirrhosis at the Tengandogo University Hospital (CHUT).
Materials and Methods: This was an analytical cross-sectional study con
ducted over a period of ten and a half years at CHUT in Ouagadougou. We
collected the medical records of patients with liver cirrhosis. Sociodemo
graphic and diagnostic data were collected. A univariate and then a multivar
iate logistic regression analysis was performed to identify factors associated
with death. Authorization from the general management of CHUT was ob
tained, and patient confidentiality was maintained. Results: The hospital mor
tality rate was 38.5% (79/205). The majority of patients were male (76.1%) and
viral hepatitis B was the main etiology (59.4%). The majority of patients were
classified as Child-Pugh B or C (92.2%). The most common complications
were ascites (78.5%), cancer (48.3%), hepatic encephalopathy (21.5%), and as
sociated infections (15.1%). In multivariate analysis, hepatic encephalopathy,
infections, and the presence of cancer were independently associated with
death, while age, sex, etiology, and Child-Pugh score were not independent
predictive factors. Conclusion: Mortality among hospitalized cirrhotic pa
tients remains high and is mainly related to cirrhosis-related complications,
reflecting late diagnosis. Strengthening HBV screening, early follow-up of patients, and optimal management of complications are essential to improve prognosis.

Mots-clés

Hepatic Cirrhosis, Mortality, Ascites, Hepatocellular Carcinoma, Burkina Faso