Prevalence of anti-hepatitis E virus antibodies in domestic animal from three representative provinces of Burkina Faso

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Résumé

Four major genotypes of Hepatitis E virus (HEV) have been documented worldwide (1–4) with genotypes 1 and 2
found in human in Sub-Saharan Africa. Human Hepatitis cases due to HEV genotype 3 and 4 are zoonotic with
various animal identified as possible reservoirs. Recently, HEV genotype 3 was found in pigs and human beings
in West Africa, which may change the epidemic in human. Here, we assessed the prevalence of HEV antibodies in
various domestic and wild mammalians in Burkina Faso. Random sampling was performed between 2015 and
2017 to collect serum from 100 rabbits (Oryctolagus cuniculus), 19 hares (Lepus africana), 72 cattle (Bos taurus),
75 sheep (Ovis aries) and 81 goats (Capra aegagrus) in three provinces in Burkina Faso. A multi-species ELISA was
performed on serum samples from 328 domestic animals and 19 hunting hares. HEV total antibodies were
identified in 121 out of 347 specimens (34.9% CI95% [29.9–39.9]). Sera from rabbits (60% CI95% [50.4–69.6]),
hares (52.6% CI95% [30.2–75.1]), cattle (26.4% CI95% [16.2–36.6]), sheep (12.0% CI95% [4.6–19.4]), and
goats (28.4% CI95% [18.6–38.2]) tested positive for antibodies anti-HEV. In this study we evidence presence of
HEV antibodies in various mammalians and highlight the importance of these species in the epidemiology of
HEV infection in Burkina Faso.

Mots-clés

Hepatitis E virus Seroprevalence Zoonosis Lagomorphs Ungulata Burkina Faso