Spontaneous resolution of cutaneous Langerhans cell histiocytosis in an infant

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Résumé

Langerhans cell histiocytosis (LCH) is a rare proliferative
disorder, characterised by an accumulation of cells sharing
the major phenotypic features of cutaneous Langerhans
cells. Given its variable evolution, ranging from self-healing
to multisystemic forms with poor prognosis, it is debated
whether it is a neoplastic or an inflammatory disease [1].
Recent genomic data support a possible common origin of
the disease in the bone marrow. Whole-exome sequencing
revealed a high frequency of activating mutations in
MAPK pathway genes in LCH. The wide range of clinical
manifestations of these disorders could therefore result
from the activation of MAPK mutations at different stages
of myeloid differentiation [2].

Mots-clés

Cutaneous Langerhans cell histiocytosis, Infant, Spontaneous resolution