Détails Publication
Genetic Factors Associated with Response to Breast Cancer Chemotherapy in Burkina Faso: Case of the CHEK2 1100delC Mutation,
Discipline: Sciences biologiques
Auteur(s): Fabienne Marie Soudre, Alice Kiba, Raoul Karfo, Arnaud Kouraogo, Mousso Savadogo, Lassina Traore, Aboubacar Bambara, Roland Some, Arsene Kagambega, Damien Konkobo, Florencia Djigma, Elie Kabre, Jacques Simpore and Jean Sakande
Renseignée par : SAKANDE Jean
Résumé

Background and Objective: Breast cancer is a major public health burden worldwide. During chemotherapy treatment, the
development of therapeutic resistance considerably compromises patients’ prognosis. The aim of this study was to investigate the
genetic factors associated with response to breast cancer treatment in patients in Burkina Faso, in particular the CHEK2 1100delC
mutation. Materials and Methods: A case-control study has been performed from January, 2020 to August, 2022. Cases were patients
with a poor response to chemotherapy according to RECIST criteria, controls were those with a good response. Specific parallel PCR has
been used to characterize the CHEK2 1100delC mutation. Results: A total of seventy-eight patients have been enrolled in the study,
including 38 cases and 40 controls. The mean age of the patients was 48.73±10.69 years. The SBRm grade II (84.62%) and non-specific
infiltrating carcinoma (91.03%) were the most common. The majority of patients (67.95%) were on their first line of chemotherapy. No
CHEK2 1100delC mutations were found among study patients. Conclusion: The management of breast cancer with chemotherapy
requires relevant data to assess response to treatment. There were no CHEK2 1100delC mutations found in the study. Further studies,
using sequencing methods, in particular, would make a considerable contribution.

Mots-clés

CHEK2 1100delC, breast cancer, chemotherapy, chemoresistance, mutation, Burkina Faso

935
Enseignants
5615
Publications
49
Laboratoires
84
Projets