Renin-Angiotensin System Genes Polymorphisms and Essential Hypertension in Burkina Faso, West Africa,
Lien de l'article:
http://dx.doi.org/10.1155/2015/979631
Auteur(s):
Daméhan Tchelougou 1, Jonas K Kologo 2, Simplice D Karou 1, Valentin N Yaméogo 2, Cyrille Bisseye 3, Florencia W Djigma 4, Djeneba Ouermi 4, Tegwindé R Compaoré 5, Maléki Assih 1, Virginio Pietra 1, Patrice Zabsonré 6, Jacques Simpore 4
Auteur(s) tagués:
Nobila Valentin YAMEOGO ;
Résumé
Objective. This study aimed to investigate the association between three polymorphisms of renin-angiotensin system and the essential hypertension in the population of Burkina Faso. Methodology. This was a case-control study including 202 cases and 204 matched controls subjects. The polymorphisms were identified by a classical and a real-time PCR. Results. The AGT 235M/T and AT1R 1166A/C polymorphisms were not associated with the hypertension while the genotype frequencies of the ACE I/D polymorphism between patients and controls (DD: 66.83% and 35.78%, ID: 28.22% and 50.98%, II: 4.95% and 13.24%, resp.) were significantly different (p
Mots-clés