Nauclea latifolia has been used in the management of malaria in the Burkina and despite its application in ethnomedicine, there is dearth of scientific evidence to justify the acclaimed prophylactic antimalarial usage of the plant. The aim of this study was designed to determine the antimalaria, immunostimulatory activities and toxicological effects of the polyphenol-rich fractions of leaves from Nauclea latifolia in animal model. The in vivo antimalaria was conducted on P. berghei infected albino mice by following 4-day test and Curative tests. The effect of oral administration of the polyphenol-rich fractions on biochemical and haematological parameters did not show any significant effect (P

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