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KIR2DL2, KIR2DL5A and KIR2DL5B Genes Induce Susceptibility to Dengue Virus Infection, while KIR3DL3 and KIR2DS5 Confer Protection,

Lien de l'article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652005/

Auteur(s): Aziz Sidi Aristide Tapsoba, Florencia Wendkuuni Djigma, Bagora Bayala, Pegdwende Abel Sorgho, Lassina Traore, Theodora Mahoukede Zohoncon, Shoukrat Ohuwa Toyin Bello, Prosper Bado, Bapio Valerie Elvira Jean Telesphore Bazie, Fiffou Yougbare, Marius Ayaovi Setor, Esther Mah Alima Traore, Dorcas Obiri-Yeboah, Albert Théophane Yonli, Jacques Simpore

Auteur(s) tagués: Lassina TRAORE ;

Résumé

Abstract. Background and Objectives: Dengue fever (DF), an emerging and re-emerging viral disease, is a major public health problem. The aim of this study was to investigate the influence of KIRs genes polymorphism and KIRs genotypes in susceptibility to dengue virus infection and disease severity in a population from Burkina Faso through a case-control study.
Methods: KIRs genes determination was performed using PCR-SSP in 50 patients infected by dengue virus (DENV) and 54 Healthy controls (HC) subjects who had never been infected.
Results: Data analysis showed significant association between frequencies of three KIR genes and dengue virus infection (DF): KIR2DL2 (OR: 7.32; IC: 2.87-18.65; P

Mots-clés

Dengue infection KIRs genes Haplotype SSP-PCR Burkina Faso

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