This study aimed to evaluate the diagnostic performance of commercially rapid point-of-care (POC)
tests used for HCV antibodies detection. This is a case-control study conducted in Ouagadougou
between December 2014 and January 2015. Three POC for HCV antibodies detection (SD Bioline HCV
test®, Anti-HCV dipstick® and First response® HCV card test) marketed in Burkina Faso were evaluated.
Architect anti-HCV assay and ImmunoComb® II HCV were combined and used as a reference test. All
three tests were evaluated with a panel of 62 anti-HCV positive sera and 62 anti-HCV negative sera. The
tests performance was calculated using the software OpenEpi. The three rapid POC tests had a
specificity of 100% (95% CI: 94.17-100). However, the sensitivities were 33.87% (95% CI: 23.34-46.28) for
the SD Bioline HCV test®, 41.94% (95% CI: 30.48-54.33%) for Anti-HCV dipstick® and 45.16% (95%CI:
33.42-57.47%) for First response® HCV card test. The tests evaluated in this study had good specificity
but poor sensitivity for the HCV antibodies detection in Burkina Faso. The surveillance of HCV rapid
POC tests through the validation of their accuracy in the local context before their approval must be
strengthened.

Hepatitis C virus point-of-care