APOL1 Renal Risk Variants and Kidney Function in HIV-1-Infected People From Sub-Saharan Africa,
Auteur(s): Nongodo Firmin Kabore 1, Amandine Cournil 2, Armel Poda 3 4, Laura Ciaffi 5, Elizabeth Binns-Roemer 6, Victor David 7, Sabrina Eymard-Duvernay 2, Jacques Zoungrana 3 4, Aoua Semde 4 8, Adrien B Sawadogo 3, Sinata Koulla-Shiro 9, Charles Kouanfack 10, Ndeye Fatou Ngom-Gueye 11, Nicolas Meda 12, Cheryl Winkler 6, Sophie Limou 6 13 14
Auteur(s) tagués: Nicolas MEDA ;
Résumé

Introduction: APOL1 G1 and G2 alleles have been associated with kidney-related outcomes in people living with HIV (PLHIV) of Black African origin. No APOL1-related kidney risk data have yet been reported in PLHIV in West Africa, where high APOL1 allele frequencies have been observed.

Methods: We collected clinical data from PLHIV followed in Burkina Faso (N = 413) and in the ANRS-12169/2LADY trial (Cameroon, Senegal, Burkina Faso, N = 369). APOL1 G1 and G2 risk variants were genotyped using TaqMan assays, and APOL1 high-risk (HR) genotype was defined by the carriage of 2 risk alleles.

Results: In West Africa (Burkina Faso and Senegal), the G1 and G2 allele frequencies were 13.3% and 10.7%, respectively. In Cameroon (Central Africa), G1 and G2 frequencies were 8.7% and 8.9%, respectively. APOL1 HR prevalence was 4.9% in West Africa and 3.4% in Cameroon. We found no direct association between APOL1 HR and estimated glomerular filtration rate (eGFR) change over time. Nevertheless, among the 2LADY cohort participants, those with both APOL1 HR and high baseline viral load had a faster eGFR progression (β = -3.9[-7.7 to -0.1] ml/min per 1.73 m2 per year, P

Mots-clés

APOL1 Africa Burkina Faso HIV Kidney risk eGFR

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