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ARTICLE

KIR2DL2, KIR2DL5A and KIR2DL5B Genes Induce Susceptibility to Dengue Virus Infection, while KIR3DL3 and KIR2DS5 Confer Protection.,

Lien de l'article: doi: 10.4084/MJHID.2022.075. eCollection 2022

Auteur(s): Fiffou Yougbare, Aziz Sidi Aristide Tapsoba, Florencia Wendkuuni Djigma, Bagora Bayala, Pegdwende Abel Sorgho, Lassina Traore, Theodora Mahoukede Zohoncon, Shoukrat Ohuwa Toyin Bello, Prosper Bado, Bapio Valerie Elvira Jean Telesphore Bazie, Fiffou Yougbare, Marius Ayaovi Setor, Esther Mah Alima Traore, Dorcas Obiri-Yeboah, Albert Theophane Yonli, Jacques Simpore

Auteur(s) tagués: Wendkuuni Florencia DJIGMA ;

Résumé

BACKGROUND AND OBJECTIVES: Dengue fever (DF), an emerging and re-emerging viral
disease, is a major public health problem. The aim of this study was to
investigate the influence of KIRs genes polymorphism and KIRs genotypes in
susceptibility to dengue virus infection and disease severity in a population
from Burkina Faso through a case-control study.
METHODS: KIRs genes determination was performed using PCR-SSP in 50 patients
infected by dengue virus (DENV) and 54 Healthy controls (HC) subjects who had
never been infected.
RESULTS: Data analysis showed significant association between frequencies of
three KIR genes and dengue virus infection (DF): KIR2DL2 (OR: 7.32; IC:
2.87-18.65; P

Mots-clés

Burkina Faso; Dengue infection; Haplotype; KIRs genes; SSP-PCR

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