Background
Viruses, which are transmitted mainly via the digestive tract, are responsible for the high morbidity
and mortality of diseases, particularly in low-income countries. Although several studies have established the prevalence and characterization of various enteric viruses in Burkina Faso, to date, no aggregate data have been released.

Objective
Our objective was to describe the available data on the prevalence and circulating genotypes of enteric pathogen viruses responsible for human infections in Burkina Faso by carrying out a systematic review and meta-analysis.

Methods
Potentially relevant studies were identifed by a search of PubMed, Science Direct, Google Scholar, university libraries and by a manual search of the reference lists of identifed studies. The search with no restrictions on language or age was limited to studies conducted only in Burkina. Study selection, data extraction, and methodological quality of the included studies were performed independently by two investigators. Heterogeneity between studies was assessed using the Cochrane Q test and I2 test statistics based on the random efects model. Comprehensive meta-analysis (CMA 3.7) was employed to compute the pooled prevalence of pathogens identifed in the studies.

Results
Forty-three (43) studies reporting 4,214 diagnosed cases in all aged human populations were selected.
Overall, 72.6% of the pathogens diagnosed were gastroenteritis, and 27.2% were entero-transmissible hepatitis
viruses. Rotavirus was the most common cause of human viral gastroenteritis, accounting for 27.7% (95% CI: 20.9 -
35.8) of the cases, followed by norovirus (16% (95% CI: 12.25 - 20.6)) and sapovirus (11.2% (95% CI: 6.2 - 19.4)). In terms of human entero-transmissible infections, hepatitis A virus (HAV) was the most prevalent (52% [95% CI: 14.2–87.7] of total antibodies), followed by hepatitis E virus (HEV) (28.3% [95% CI: 17.7–42]).

Conclusions This study highlights the substantial burden of viral enteric infections and highlights the need for more
molecular epidemiological studies to improve preventive measures against these viruses.

Gastroenteric viruses Enteric hepatitis viruses Systematic review and meta-analysis Burkina Faso